(1S,2R)-2-(4'-anisylbenzylamino)-1-phenyl-1-[(tert-butyldimethylsilyl)oxy]propane

Base Information

Chemical Name:(1S,2R)-2-(4'-anisylbenzylamino)-1-phenyl-1-[(tert-butyldimethylsilyl)oxy]propane
CAS No.:750118-59-3
Molecular Formula:C₂₉H₃₉NO₂Si
Molecular Weight:461.72
Hs Code.:

Synonyms:(1S,2R)-2-(4'-anisylbenzylamino)-1-phenyl-1-[(tert-butyldimethylsilyl)oxy]propane

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Chemical Property of (1S,2R)-2-(4'-anisylbenzylamino)-1-phenyl-1-[(tert-butyldimethylsilyl)oxy]propane

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Technology Process of (1S,2R)-2-(4'-anisylbenzylamino)-1-phenyl-1-[(tert-butyldimethylsilyl)oxy]propane

There total 4 articles about (1S,2R)-2-(4'-anisylbenzylamino)-1-phenyl-1-[(tert-butyldimethylsilyl)oxy]propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: 750118-52-6
(1S,2R)-2-(4-bromobenzylamino)-1-phenyl-1-[(tert-butyldimethylsilyl)oxy]propane

: 750118-59-3
(1S,2R)-2-(4'-anisylbenzylamino)-1-phenyl-1-[(tert-butyldimethylsilyl)oxy]propane

Guidance literature:: (1S,2R)-2-(4-bromobenzylamino)-1-phenyl-1-[(tert-butyldimethylsilyl)oxy]propane; With potassium acetate; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at 80 ℃; for 2h;

1-bromo-4-methoxy-benzene; With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at 80 ℃;
DOI:10.1021/jo049479u

Reference yield:

: 37577-28-9,58550-13-3,757124-50-8
(1S,2R)-(+)-norphedrine

: 750118-59-3
(1S,2R)-2-(4'-anisylbenzylamino)-1-phenyl-1-[(tert-butyldimethylsilyl)oxy]propane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 79 percent / imidazole / tetrahydrofuran / Heating

2.1: 63 percent / Et₃N / tetrahydrofuran / Heating

3.1: bis(pinacolato)diboron; potassium acetate / Pd(dppf)Cl₂*CH₂Cl₂ / tetrahydrofuran / 2 h / 80 °C

3.2: 76 percent / sodium carbonate / Pd(dppf)Cl₂*CH₂Cl₂ / tetrahydrofuran / 80 °C

With 1H-imidazole; potassium acetate; triethylamine; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 3.1: Suzuki coupling / 3.2: Suzuki coupling;
DOI:10.1021/jo049479u

Reference yield:

: 150198-11-1
<(1S,2R)-1-<(tert-butyldimethylsilyl)oxy>-1-phenylpropan-2-yl>amine

: 750118-59-3
(1S,2R)-2-(4'-anisylbenzylamino)-1-phenyl-1-[(tert-butyldimethylsilyl)oxy]propane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 63 percent / Et₃N / tetrahydrofuran / Heating

2.1: bis(pinacolato)diboron; potassium acetate / Pd(dppf)Cl₂*CH₂Cl₂ / tetrahydrofuran / 2 h / 80 °C

2.2: 76 percent / sodium carbonate / Pd(dppf)Cl₂*CH₂Cl₂ / tetrahydrofuran / 80 °C

With potassium acetate; triethylamine; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 2.1: Suzuki coupling / 2.2: Suzuki coupling;
DOI:10.1021/jo049479u