3,5-bis(trifluoromethyl)benzyl N-(tert-butoxycarbonyl)-L-tryptophanate

Base Information

• Chemical Name: 3,5-bis(trifluoromethyl)benzyl N-(tert-butoxycarbonyl)-L-tryptophanate
• CAS No.: 169673-06-7
• Molecular Formula: C₂₅H₂₄F₆N₂O₄
• Molecular Weight: 530.467
• Mol file: 169673-06-7.mol

Synonyms:3,5-bis(trifluoromethyl)benzyl N-(tert-butoxycarbonyl)-L-tryptophanate

Chemical Property of 3,5-bis(trifluoromethyl)benzyl N-(tert-butoxycarbonyl)-L-tryptophanate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3,5-bis(trifluoromethyl)benzyl N-(tert-butoxycarbonyl)-L-tryptophanate

There total 1 articles about 3,5-bis(trifluoromethyl)benzyl N-(tert-butoxycarbonyl)-L-tryptophanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Boc-Trp-OH (13139-14-5) + 3,5-bis(trifluoromethyl)benzyl bromide (32247-96-4) → 3,5-bis(trifluoromethyl)benzyl N-(tert-butoxycarbonyl)-L-tryptophanate (169673-06-7)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; for 18h;

DOI:10.3390/ijms23031214

Reference yield: 81.0%

3,5-bis(trifluoromethyl)benzyl N-(tert-butoxycarbonyl)-L-tryptophanate (169673-06-7) + trifluoroacetic acid (76-05-1) → (S)-1-((3,5-bis(trifluoromethyl)benzyl)oxy)-3-(1H-indol-3-yl)-1-oxopropan-2-aminium mono-2,2,2-trifluoroacetate

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

DOI:10.3390/ijms23031214

Reference yield:

3,5-bis(trifluoromethyl)benzyl N-(tert-butoxycarbonyl)-L-tryptophanate (169673-06-7) → tryptophan 3',5'-(bistrifluoromethyl)benzyl ester hydrochloride

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 16h;

DOI:10.1021/jm00035a006

upstream raw materials:

Boc-Trp-OH

3,5-bis(trifluoromethyl)benzyl bromide