(S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-[3-(4-hydroxy-benzyl)-ureido]-butyric acid tert-butyl ester

Base Information

Chemical Name:(S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-[3-(4-hydroxy-benzyl)-ureido]-butyric acid tert-butyl ester
CAS No.:197969-48-5
Molecular Formula:C₂₇H₄₃N₃O₅
Molecular Weight:489.656
Hs Code.:

Synonyms:(S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-[3-(4-hydroxy-benzyl)-ureido]-butyric acid tert-butyl ester

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Chemical Property of (S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-[3-(4-hydroxy-benzyl)-ureido]-butyric acid tert-butyl ester

Chemical Property:

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Technology Process of (S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-[3-(4-hydroxy-benzyl)-ureido]-butyric acid tert-butyl ester

There total 3 articles about (S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-[3-(4-hydroxy-benzyl)-ureido]-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 197969-47-4
(S)-4-[3-(4-Benzyloxy-benzyl)-ureido]-4-[(3-cyclohexyl-propyl)-methyl-carbamoyl]-butyric acid tert-butyl ester

: 197969-48-5
(S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-[3-(4-hydroxy-benzyl)-ureido]-butyric acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 12h; under 760 Torr;
DOI:10.1021/jm970402q

Reference yield:

: 189393-55-3
(S)-4-Amino-4-[(3-cyclohexyl-propyl)-methyl-carbamoyl]-butyric acid tert-butyl ester

: 197969-48-5
(S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-[3-(4-hydroxy-benzyl)-ureido]-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaHCO₃ / CH₂Cl₂; toluene / 0.08 h

2: Et₃N / CH₂Cl₂ / 1 h

3: H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 12 h / 760 Torr

With hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm970402q

Reference yield:

: 189393-56-4
(S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-isocyanato-butyric acid tert-butyl ester

: 197969-48-5
(S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-[3-(4-hydroxy-benzyl)-ureido]-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 1 h

2: H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 12 h / 760 Torr

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm970402q