(E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)aniline]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethyl-d6-amino)-2-butenamide

Base Information

Chemical Name:(E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)aniline]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethyl-d6-amino)-2-butenamide
CAS No.:1259519-18-0
Molecular Formula:C₃₀H₂₉ClN₆O₃
Molecular Weight:563.004
Hs Code.:

Synonyms:(E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)aniline]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethyl-d6-amino)-2-butenamide

Suppliers and Price of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)aniline]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethyl-d6-amino)-2-butenamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Neratinib-d6
10mg
$ 2725.00

Total 4 raw suppliers

Chemical Property of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)aniline]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethyl-d6-amino)-2-butenamide

Chemical Property:

Purity/Quality:

≥96%; ≥99% atom D ^*data from raw suppliers

Neratinib-d6 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Labelled Neratinib (N390090). An oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer. Antitumor agent.

Technology Process of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)aniline]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethyl-d6-amino)-2-butenamide

There total 1 articles about (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)aniline]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethyl-d6-amino)-2-butenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 848139-78-6
6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile

: 1259519-59-9
(E)-4-(dimethyl-d6-amino)but-2-enoic acid hydrochloride

: 1259519-18-0
(E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)aniline]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethyl-d6-amino)-2-butenamide

Guidance literature:: (E)-4-(dimethyl-d6-amino)but-2-enoic acid hydrochloride; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 5 - 20 ℃;

6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃;

With sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; for 1h; pH=11;