4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthio-6-phenylpyrimidine

Base Information

Chemical Name:4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthio-6-phenylpyrimidine
CAS No.:1373425-72-9
Molecular Formula:C₃₇H₄₄N₂O₄SSi
Molecular Weight:640.919
Hs Code.:

Synonyms:4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthio-6-phenylpyrimidine

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Chemical Property of 4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthio-6-phenylpyrimidine

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Technology Process of 4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthio-6-phenylpyrimidine

There total 3 articles about 4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthio-6-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1352789-45-7
1-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)-5-phenylpent-4-yn-3-one

: 14527-26-5,867-44-7,147895-43-0
2-methylisothiourea sulphate

: 1373425-72-9
4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthio-6-phenylpyrimidine

Guidance literature:: With water; sodium carbonate; In ethyl acetate; for 24h; Reflux;
DOI:10.3998/ark.5550190.0013.310

Reference yield:

: 1352789-20-8
3-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranosyl-1-yl)propanal

: 1373425-72-9
4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthio-6-phenylpyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 4 h / 20 °C

3: water; sodium carbonate / ethyl acetate / 24 h / Reflux

With water; sodium carbonate; In tetrahydrofuran; ethyl acetate; 2: |Dess-Martin Oxidation;
DOI:10.3998/ark.5550190.0013.310

Reference yield:

: 1352789-41-3
(3R,S)-1-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)-5-phenylpent-4-yn-3-ol

: 1373425-72-9
4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthio-6-phenylpyrimidine

Guidance literature:: Multi-step reaction with 2 steps

2: water; sodium carbonate / ethyl acetate / 24 h / Reflux

With water; sodium carbonate; In ethyl acetate; 1: |Dess-Martin Oxidation;
DOI:10.3998/ark.5550190.0013.310