benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

Base Information

Chemical Name:benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate
CAS No.:654068-59-4
Molecular Formula:C₃₀H₃₉ClN₂O₇
Molecular Weight:575.102
Hs Code.:

Synonyms:benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

Suppliers and Price of benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

There total 1 articles about benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57292-44-1
N-Boc-D-(4-Cl)Phe-OH

: (S)-2-(3-Amino-propionyloxy)-4-methyl-pentanoic acid benzyl ester; compound with trifluoro-acetic acid

: 654068-59-4
benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 16.5h;
DOI:10.1021/jm030278c

Reference yield:

: 654068-59-4
benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

: 10-(4'-chlorobenzyl)demethoxybenzylcryptophycin-24

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Pd(OH)2 / ethyl acetate / 2 h

2.1: 2,4,6-trichlorobenzoyl chloride; DIEA; DMAP / tetrahydrofuran / 2 h

2.2: 0.19 g / tetrahydrofuran / 2 h / 20 °C

3.1: CH₂Cl₂ / 2 h / 20 °C

4.1: 0.051 g / HBTU; DIEA / acetonitrile / 3 h / 20 °C

5.1: dimethyldioxirane / acetone / 5 h / 20 °C

With dmap; 2,4,6-trichlorobenzoyl chloride; hydrogen; 3,3-dimethyldioxirane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm030278c

Reference yield:

: 654068-59-4
benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

: (E)-(3S,10R,16S)-10-(4-Chloro-benzyl)-3-isobutyl-16-[(S)-1-((2S,3S)-3-phenyl-oxiranyl)-ethyl]-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Pd(OH)2 / ethyl acetate / 2 h

2.1: 2,4,6-trichlorobenzoyl chloride; DIEA; DMAP / tetrahydrofuran / 2 h

2.2: 0.19 g / tetrahydrofuran / 2 h / 20 °C

3.1: CH₂Cl₂ / 2 h / 20 °C

4.1: 0.051 g / HBTU; DIEA / acetonitrile / 3 h / 20 °C

5.1: dimethyldioxirane / acetone / 5 h / 20 °C

With dmap; 2,4,6-trichlorobenzoyl chloride; hydrogen; 3,3-dimethyldioxirane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm030278c