DAz-1

Base Information

Chemical Name:DAz-1
CAS No.:1112977-84-0
Molecular Formula:C₁₀H₁₄N₄O₃
Molecular Weight:238.246
Hs Code.:
Mol file:1112977-84-0.mol

Synonyms:DAz-1

Suppliers and Price of DAz-1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
DAZ1
100ul
$ 516.00

Cayman Chemical
DAz-1 ≥98%
5mg
$ 516.00

Cayman Chemical
DAz-1 ≥98%
1mg
$ 116.00

Cayman Chemical
DAz-1 ≥98%
10mg
$ 917.00

Biorbyt Ltd
DAZ1
10 μg
$ 1004.70

AK Scientific
N-(3-Azidopropyl)-3,5-dioxocyclohexane-1-carboxamide
10mg
$ 1244.00

AK Scientific
N-(3-Azidopropyl)-3,5-dioxocyclohexane-1-carboxamide
5mg
$ 743.00

AK Scientific
N-(3-Azidopropyl)-3,5-dioxocyclohexane-1-carboxamide
1mg
$ 243.00

Total 18 raw suppliers

Chemical Property of DAz-1

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

DAZ1 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Redox-sensitive cysteine residues in proteins may function as sensors of reactive oxygen species (ROS) and also serve as molecular switches, activating or deactivating proteins, following a change in oxidation state. Modification of protein function through the reversible oxidation of cysteine is emerging as a biologically relevant signal transduction mechanism. Sulfenic acid is the initial oxidation product of cysteine by relatively mild oxidizing agents such as hydrogen peroxide. Sulfenic acid can be reduced back to the free thiol or be further oxidized to sulfinic and sulfonic acids. DAz-1 is a cell-permeable chemical probe that reacts specifically with sulfenic acid-modified proteins. The azido group of DAz-1 provides a method for selective conjugation to phosphine- or alkynyl- derivatized reagents, such as biotin or various fluorophores, for subsequent analysis of the labeled proteins. DAz-1 is a less sensitive probe for sulfenic acid detection compared to its analog DAz-2 .

Technology Process of DAz-1

There total 3 articles about DAz-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1112977-83-9
C₁₁H₁₆N₄O₃

: 1112977-84-0
DAz-1

Guidance literature:: With ammonium cerium (IV) nitrate; water; In acetonitrile; at 20 ℃; for 1h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2008.11.073

Reference yield:

: 42858-60-6
3,5-cyclohexanedione-1-carboxylic acid

: 1112977-84-0
DAz-1

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / 0.17 h / 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; water; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2008.11.073

Reference yield:

: 95298-68-3
3-methoxy-5-oxo-cyclohex-3-ene-1-carboxylic acid

: 1112977-84-0
DAz-1

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2008.11.073