(+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-5,7-dichloro-4-oxo-3,4-dihydro-pyrrolo-[2,1-f][1,2,4]triazine-2-yl)propyl]amine

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Chemical Name:(+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-5,7-dichloro-4-oxo-3,4-dihydro-pyrrolo-[2,1-f][1,2,4]triazine-2-yl)propyl]amine
CAS No.:628734-13-4
Molecular Formula:C₂₄H₃₁Cl₂N₅O₃
Molecular Weight:508.448
Hs Code.:

Synonyms:(+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-5,7-dichloro-4-oxo-3,4-dihydro-pyrrolo-[2,1-f][1,2,4]triazine-2-yl)propyl]amine

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Chemical Property of (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-5,7-dichloro-4-oxo-3,4-dihydro-pyrrolo-[2,1-f][1,2,4]triazine-2-yl)propyl]amine

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Technology Process of (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-5,7-dichloro-4-oxo-3,4-dihydro-pyrrolo-[2,1-f][1,2,4]triazine-2-yl)propyl]amine

There total 10 articles about (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-5,7-dichloro-4-oxo-3,4-dihydro-pyrrolo-[2,1-f][1,2,4]triazine-2-yl)propyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (+/-)-2-(1-aminopropyl)-3-benzyl-5,7-dichloro-3-H-pyrrolo[2,1-f][1,2,4]triazine-4-one

: 58885-60-2
N-(tert-butoxycarbonyl)-3-aminopropanal

: 628734-13-4
(+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-5,7-dichloro-4-oxo-3,4-dihydro-pyrrolo-[2,1-f][1,2,4]triazine-2-yl)propyl]amine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In methanol; at 20 ℃; for 2.5h;

Reference yield:

: 1-amino-3,5-dichloro-1H-pyrrole-2-carboxylic acid methyl ester

: 628734-13-4
(+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-5,7-dichloro-4-oxo-3,4-dihydro-pyrrolo-[2,1-f][1,2,4]triazine-2-yl)propyl]amine

Guidance literature:: Multi-step reaction with 8 steps

1: HCl / dioxane / 82 °C

2: Et₃N / acetonitrile / 85 °C

3: Cs₂CO₃ / dioxane / 95 °C

4: MgSO₄ / dimethylformamide / 146 °C

5: NaIO₄ / various solvent(s); tetrahydrofuran / 20 °C / pH 7

6: CH₂Cl₂ / -78 - -50 °C

7: SOCl₂; pyridine / CH₂Cl₂ / 0 - 20 °C

8: ethanol / Heating

With pyridine; hydrogenchloride; sodium periodate; thionyl chloride; magnesium sulfate; caesium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.05.037

Reference yield:

: 5,7-dichloro-2-methyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

: 628734-13-4
(+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-5,7-dichloro-4-oxo-3,4-dihydro-pyrrolo-[2,1-f][1,2,4]triazine-2-yl)propyl]amine

Guidance literature:: Multi-step reaction with 6 steps

1: Cs₂CO₃ / dioxane / 95 °C

2: MgSO₄ / dimethylformamide / 146 °C

3: NaIO₄ / various solvent(s); tetrahydrofuran / 20 °C / pH 7

4: CH₂Cl₂ / -78 - -50 °C

5: SOCl₂; pyridine / CH₂Cl₂ / 0 - 20 °C

6: ethanol / Heating

With pyridine; sodium periodate; thionyl chloride; magnesium sulfate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.037