Bevenopran

Base Information

Chemical Name:Bevenopran
CAS No.:676500-67-7
Molecular Formula:C₂₀H₂₆N₄O₄
Molecular Weight:386.451
Hs Code.:
UNII:IC58Q2EHPJ
ChEMBL ID:CHEMBL3039511
DSSTox Substance ID:DTXSID90217963
Metabolomics Workbench ID:153449
NCI Thesaurus Code:C169810
Wikidata:Q25100535
Wikipedia:Bevenopran
Mol file:676500-67-7.mol

Synonyms:Bevenopran;676500-67-7;5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide;UNII-IC58Q2EHPJ;5-[2-methoxy-4-[[2-(oxan-4-yl)ethylamino]methyl]phenoxy]pyrazine-2-carboxamide;CB5945;IC58Q2EHPJ;CB-5945;ADL-5945;ADL5945;2-PYRAZINECARBOXAMIDE, 5-[2-METHOXY-4-[[[2-(TETRAHYDRO-2H-PYRAN-4-YL)ETHYL]AMINO]METHYL]PHENOXY]-;CB5-945;Bevenopran [USAN];Bevenopran [USAN:INN];2-PYRAZINECARBOXAMIDE, 5-(2-METHOXY-4-(((2-(TETRAHYDRO-2H-PYRAN-4-YL)ETHYL)AMINO)METHYL)PHENOXY)-;5-[2-Methoxy-4-({[2-(tetrahydro-2H-pyran-4-yl)ethyl]amino}methyl)phenoxy]pyrazine-2-carboxamide;BEVENOPRAN [INN];Bevenopran (USAN/INN);BEVENOPRAN [WHO-DD];SCHEMBL1462219;CHEMBL3039511;DTXSID90217963;CHEBI:177636;ZGCYVRNZWGUXNQ-UHFFFAOYSA-N;C20H26N4O4;BCB50067;AKOS027254823;DB12464;SB16949;DS-10418;HY-100122;CS-0018101;NS00072295;D10349;P14116;A917492;Q25100535;5-(2-Methoxy-4-{[2-(tetrahydropyran-4-yl)ethylamino]methyl}phenoxy)pyrazine-2-carboxamide;2-Pyrazinecarboxamide, 5-(2-methoxy-4-(((2-(tetrahydro-2H-pyran-4- yl)ethyl)amino)methyl)phenoxy)-;5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2- carboxamide;PYRAZINECARBOXAMIDE, 5-(2-METHOXY-4-(((2-(TETRAHYDRO-2H-PYRAN-4-YL)ETHYL)AMINO)METHYL)PHENOXY)-

Suppliers and Price of Bevenopran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Bevenopran
10mg
$ 50.00

Crysdot
5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide 95+%
5g
$ 743.00

Crysdot
5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide 95+%
1g
$ 248.00

Chemenu
5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide 95%+
1g
$ 234.00

Chemenu
5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide 95%+
5g
$ 701.00

Alichem
5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide
5g
$ 742.50

Alichem
5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide
1g
$ 272.50

Total 10 raw suppliers

Chemical Property of Bevenopran

Chemical Property:

Melting Point:133 - 136 °C
Boiling Point:575.0±50.0 °C(Predicted)
PKA:14.06±0.50(Predicted)
Density:1.204±0.06 g/cm3(Predicted)
Storage Temp.:Refrigerator, under inert atmosphere
Solubility.:Acetonitrile (Slightly), Chloroform (Slightly)
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:386.19540532
Heavy Atom Count:28
Complexity:475

Purity/Quality:

99%, ^*data from raw suppliers

Bevenopran ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)CNCCC2CCOCC2)OC3=NC=C(N=C3)C(=O)N
Recent ClinicalTrials:Evaluation of the Efficacy and Safety of ADL5945 Once Daily for the Treatment of Opioid-induced Constipation in Adults Taking Opioid Therapy for Chronic Noncancer Pain
Uses Bevenopran, is a peripheral μ-opioid receptor antagonist.

Technology Process of Bevenopran

There total 1 articles about Bevenopran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%