2-(5-formyl-2,4-dimethoxy-phenyl)-indole-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 2-(5-formyl-2,4-dimethoxy-phenyl)-indole-1-carboxylic acid tert-butyl ester
• CAS No.: 552845-78-0
• Molecular Formula: C₂₂H₂₃NO₅
• Molecular Weight: 381.428

Synonyms:2-(5-formyl-2,4-dimethoxy-phenyl)-indole-1-carboxylic acid tert-butyl ester

Chemical Property of 2-(5-formyl-2,4-dimethoxy-phenyl)-indole-1-carboxylic acid tert-butyl ester

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Technology Process of 2-(5-formyl-2,4-dimethoxy-phenyl)-indole-1-carboxylic acid tert-butyl ester

There total 1 articles about 2-(5-formyl-2,4-dimethoxy-phenyl)-indole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-bromo-2, 4-dimethoxybenzaldehyde (130333-46-9) + N-Boc-indole-2-boronic acid (213318-44-6) → 2-(5-formyl-2,4-dimethoxy-phenyl)-indole-1-carboxylic acid tert-butyl ester (552845-78-0)

Guidance literature:

With potassium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃;

DOI:10.1021/jm0614230

Reference yield: 30.0%

2-(5-formyl-2,4-dimethoxy-phenyl)-indole-1-carboxylic acid tert-butyl ester (552845-78-0) → 5-(1H-indol-2-yl)-2,4-dimethoxybenzaldehyde (552846-02-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 96h;

Reference yield: 8.0%

2-(5-formyl-2,4-dimethoxy-phenyl)-indole-1-carboxylic acid tert-butyl ester (552845-78-0) + 4-acetyl-benzoic acid (586-89-0) → C31H29NO7

Guidance literature:

With sodium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm0614230

upstream raw materials:

5-bromo-2, 4-dimethoxybenzaldehyde

N-Boc-indole-2-boronic acid

Downstream raw materials:

5-(1H-indol-2-yl)-2,4-dimethoxybenzaldehyde

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