N-{3-[5-(3-amino-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-2-methyl-phenyl}-4-tert-butyl-benzamide

Base Information

Chemical Name:N-{3-[5-(3-amino-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-2-methyl-phenyl}-4-tert-butyl-benzamide
CAS No.:910232-74-5
Molecular Formula:C₃₀H₃₂N₄O₂
Molecular Weight:480.61
Hs Code.:

Synonyms:N-{3-[5-(3-amino-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-2-methyl-phenyl}-4-tert-butyl-benzamide

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Chemical Property of N-{3-[5-(3-amino-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-2-methyl-phenyl}-4-tert-butyl-benzamide

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Technology Process of N-{3-[5-(3-amino-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-2-methyl-phenyl}-4-tert-butyl-benzamide

There total 9 articles about N-{3-[5-(3-amino-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-2-methyl-phenyl}-4-tert-butyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(tert-butyl)-N-(2-methyl-3-(1-methyl-5-((3-nitrophenyl)amino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)benzamide

: 910232-74-5
N-{3-[5-(3-amino-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-2-methyl-phenyl}-4-tert-butyl-benzamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h;
DOI:10.1016/j.ejmech.2017.03.001

Reference yield:

: 5-bromo-1-methyl-3-((3-nitrophenyl)amino)pyridin-2(1H)-one

: 910232-74-5
N-{3-[5-(3-amino-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-2-methyl-phenyl}-4-tert-butyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 110 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; In 1,4-dioxane; methanol; water; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2017.03.001

Reference yield:

: 14529-54-5
3,5-dibromo-1-methyl-1H-pyridin-2-one

: 910232-74-5
N-{3-[5-(3-amino-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-2-methyl-phenyl}-4-tert-butyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 110 °C / Inert atmosphere; Sealed tube

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 110 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; water; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2017.03.001