3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one

Base Information

Chemical Name:3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
CAS No.:1351564-28-7
Molecular Formula:C₁₆H₁₃F₆N₅O₃
Molecular Weight:437.301
Hs Code.:

Synonyms:3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one

There total 4 articles about 3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1351564-27-6
3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-3-en-1-one

: 1351564-28-7
3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one

Guidance literature:: 3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-3-en-1-one; With sodium tetrahydroborate; In tetrahydrofuran; isopropyl alcohol; at 0 ℃; for 3h;

With phosphoric acid; In tetrahydrofuran; water; isopropyl alcohol;

With sodium hydroxide; In dichloromethane; water; pH=8; Product distribution / selectivity;

Reference yield:

: 3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)propan-1-one

: 1351564-28-7
3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate / acetonitrile / 20 h / 20 °C

2.1: methanesulfonyl chloride; pyridine / 4 h / 20 °C

3.1: sodium tetrahydroborate / isopropyl alcohol; tetrahydrofuran / 3 h / 0 °C

3.3: pH 8

With pyridine; sodium tetrahydroborate; potassium phosphate; methanesulfonyl chloride; In tetrahydrofuran; isopropyl alcohol; acetonitrile;

Reference yield:

: 762240-92-6
3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

: 1351564-28-7
3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / acetonitrile / 20 h / 0 - 20 °C

2.1: potassium phosphate / acetonitrile / 20 h / 20 °C

3.1: methanesulfonyl chloride; pyridine / 4 h / 20 °C

4.1: sodium tetrahydroborate / isopropyl alcohol; tetrahydrofuran / 3 h / 0 °C

4.3: pH 8

With 4-methyl-morpholine; pyridine; sodium tetrahydroborate; potassium phosphate; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; isopropyl alcohol; acetonitrile;