(1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-(4-bromophenyl)octahydropyrrolo[3,4-c]pyrrole-1-N-methyl,N-methoxycarboxamide

Base Information

Chemical Name:(1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-(4-bromophenyl)octahydropyrrolo[3,4-c]pyrrole-1-N-methyl,N-methoxycarboxamide
CAS No.:1357917-75-9
Molecular Formula:C₁₆H₁₈BrN₃O₄
Molecular Weight:396.241
Hs Code.:

Synonyms:(1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-(4-bromophenyl)octahydropyrrolo[3,4-c]pyrrole-1-N-methyl,N-methoxycarboxamide

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Chemical Property of (1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-(4-bromophenyl)octahydropyrrolo[3,4-c]pyrrole-1-N-methyl,N-methoxycarboxamide

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Technology Process of (1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-(4-bromophenyl)octahydropyrrolo[3,4-c]pyrrole-1-N-methyl,N-methoxycarboxamide

There total 2 articles about (1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-(4-bromophenyl)octahydropyrrolo[3,4-c]pyrrole-1-N-methyl,N-methoxycarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 930-88-1
N-methylmaleimide

: 1357917-89-5
2-[(4-bromobenzylidene)amino]-N-methyl-N-methoxyacetamide

: 1357917-75-9
(1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-(4-bromophenyl)octahydropyrrolo[3,4-c]pyrrole-1-N-methyl,N-methoxycarboxamide

Guidance literature:: With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; triethylamine; In tetrahydrofuran; at 20 ℃; for 18h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c2cc17149j

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1357917-75-9
(1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-(4-bromophenyl)octahydropyrrolo[3,4-c]pyrrole-1-N-methyl,N-methoxycarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium sulfate / dichloromethane / 40 °C / Inert atmosphere

2: (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; triethylamine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; magnesium sulfate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2cc17149j