4-(4-Acryloylamino-piperidine-1-sulfonyl)-2-fluoro-N-phenethyl-benzamide

Base Information

Chemical Name:4-(4-Acryloylamino-piperidine-1-sulfonyl)-2-fluoro-N-phenethyl-benzamide
CAS No.:1414967-63-7
Molecular Formula:C₂₃H₂₆FN₃O₄S
Molecular Weight:459.542
Hs Code.:

Synonyms:4-(4-Acryloylamino-piperidine-1-sulfonyl)-2-fluoro-N-phenethyl-benzamide

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Chemical Property of 4-(4-Acryloylamino-piperidine-1-sulfonyl)-2-fluoro-N-phenethyl-benzamide

Chemical Property:

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Technology Process of 4-(4-Acryloylamino-piperidine-1-sulfonyl)-2-fluoro-N-phenethyl-benzamide

There total 5 articles about 4-(4-Acryloylamino-piperidine-1-sulfonyl)-2-fluoro-N-phenethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1414968-14-1
4-(4-Amino-piperidine-1-sulfonyl)-2-fluoro-N-phenethyl-benzamide

: 814-68-6,25189-84-8
acryloyl chloride

: 1414967-63-7
4-(4-Acryloylamino-piperidine-1-sulfonyl)-2-fluoro-N-phenethyl-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1414968-11-8
4-(4-tert-Butoxycarbonylamino-piperidine-1-sulfonyl)-2-fluoro-benzoic acid methyl ester

: 1414967-63-7
4-(4-Acryloylamino-piperidine-1-sulfonyl)-2-fluoro-N-phenethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

2.1: thionyl chloride; pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2.2: 12 h

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; thionyl chloride; water; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 1414968-12-9
4-(4-tert-butoxycarbonylamino-piperidine-1-sulfonyl)-2-fluoro-benzoic acid

: 1414967-63-7
4-(4-Acryloylamino-piperidine-1-sulfonyl)-2-fluoro-N-phenethyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere

1.2: 12 h

2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; thionyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;