(2-{[4-azido-2-fluorocyclohexyl]oxy}-1-phenylethoxy)(tert-butyl)dimethylsilane

Base Information

Chemical Name:(2-{[4-azido-2-fluorocyclohexyl]oxy}-1-phenylethoxy)(tert-butyl)dimethylsilane
CAS No.:847417-21-4
Molecular Formula:C₂₀H₃₂FN₃O₂Si
Molecular Weight:393.577
Hs Code.:

Synonyms:(2-{[4-azido-2-fluorocyclohexyl]oxy}-1-phenylethoxy)(tert-butyl)dimethylsilane

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Chemical Property of (2-{[4-azido-2-fluorocyclohexyl]oxy}-1-phenylethoxy)(tert-butyl)dimethylsilane

Chemical Property:

Purity/Quality:

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Technology Process of (2-{[4-azido-2-fluorocyclohexyl]oxy}-1-phenylethoxy)(tert-butyl)dimethylsilane

There total 6 articles about (2-{[4-azido-2-fluorocyclohexyl]oxy}-1-phenylethoxy)(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(2-{[tert-butyl(dimethyl)silyl]oxy}-2-phenylethoxy)-3-fluorocyclohexyl methanesulfonate

: 847417-21-4
(2-{[4-azido-2-fluorocyclohexyl]oxy}-1-phenylethoxy)(tert-butyl)dimethylsilane

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 90 ℃; for 2h;

Reference yield:

: 847417-17-8
2-{[4-(benzyloxy)-2-fluorocyclohexyl]oxy}-1-phenylethanol

: 847417-21-4
(2-{[4-azido-2-fluorocyclohexyl]oxy}-1-phenylethoxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 0 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.02 h / 0 °C

4: sodium azide / N,N-dimethyl-formamide / 2 h / 90 °C

With sodium azide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: (-) 2-{[4-(benzyloxy)-2-fluorocyclohexyl]oxy}-1-phenylethanone

: 847417-21-4
(2-{[4-azido-2-fluorocyclohexyl]oxy}-1-phenylethoxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 0.25 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 0 °C

3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.02 h / 0 °C

5: sodium azide / N,N-dimethyl-formamide / 2 h / 90 °C

With sodium tetrahydroborate; sodium azide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;