Diflucortolone valerate

Base Information

• Chemical Name: Diflucortolone valerate
• CAS No.: 59198-70-8
• Molecular Formula: C27H36F2O5
• Molecular Weight: 478.577
• European Community (EC) Number: 261-655-8
• UNII: 1A63Z067C8
• DSSTox Substance ID: DTXSID1048598
• Nikkaji Number: J12.073A
• Wikipedia: Diflucortolone_valerate
• Wikidata: Q10860261
• ChEMBL ID: CHEMBL2358130
• Mol file: 59198-70-8.mol

Synonyms:Claral;diflucortolone valerate;Nerisona;Nerisone;Nerisone Forte;Temetex

Chemical Property of Diflucortolone valerate

Chemical Property:

• Vapor Pressure: 8.58E-16mmHg at 25°C
• Melting Point: 220 °C
• Refractive Index: 1.538
• Boiling Point: 578.5 °C at 760 mmHg
• PKA: 12.89±0.70(Predicted)
• Flash Point: 303.7 °C
• PSA: 80.67000
• Density: 1.225 g/cm³
• LogP: 4.46990
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly)
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 478.25308057
• Heavy Atom Count: 34
• Complexity: 943

Purity/Quality:

99% ^*data from raw suppliers

Diflucortolone21-Valerate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC(=O)OCC(=O)C1C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C
• Isomeric SMILES: CCCCC(=O)OCC(=O)[C@H]1[C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C
• Recent ClinicalTrials: An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids
• Uses: The 9α-fluoro derivative of Fluocortolone (F500500). Anti-inflammmatory.
• Therapeutic Function: Antiinflammatory

Technology Process of Diflucortolone valerate

There total 1 articles about Diflucortolone valerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6α,9-difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-valerate (59198-70-8)

Guidance literature:

Epoxid 8d, HF;