Technology Process of (7S,9aS)-7-[(benzyloxy)methyl]octahydropyrazino[2,1-c][1,4]oxazine
There total 5 articles about (7S,9aS)-7-[(benzyloxy)methyl]octahydropyrazino[2,1-c][1,4]oxazine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
acetonitrile;
at 60 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 35 - 40 °C / Industry scale
1.2: 40 °C / Industry scale
1.3: 2.25 h / 5 - 15 °C / Industry scale
2.1: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol / 3 h / 20 - 30 °C / 2311.54 Torr / Industry scale
3.1: N-ethyl-N,N-diisopropylamine / ethanol / 0.17 h / 25 °C / Industry scale
3.2: 1 h / 25 °C / Industry scale
3.3: 0.83 h / 25 - 30 °C / Industry scale
4.1: borane-THF / tetrahydrofuran / 4.5 h / 35 - 45 °C / Inert atmosphere; Industry scale
5.1: triethylamine; methanesulfonyl chloride / dichloromethane; Isopropyl acetate / 20 h / 5 - 20 °C
6.1: hydrogenchloride / water; Isopropyl acetate / 1 h / 10 - 25 °C
6.2: 2 - 20 °C / pH ~ 7
7.1: triethylamine / acetonitrile / 60 °C
With
hydrogenchloride; borane-THF; dimethylsulfide borane complex; hydrogen; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine;
20% palladium(II) hydroxide on carbon;
In
tetrahydrofuran; ethanol; dichloromethane; Isopropyl acetate; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride / water; Isopropyl acetate / 1 h / 10 - 25 °C
1.2: 2 - 20 °C / pH ~ 7
2.1: triethylamine / acetonitrile / 60 °C
With
hydrogenchloride; triethylamine;
In
Isopropyl acetate; water; acetonitrile;
