methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate

Base Information

Chemical Name:methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate
CAS No.:1364596-14-4
Molecular Formula:C₁₆H₁₄ClN₃O₃
Molecular Weight:331.758
Hs Code.:

Synonyms:methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate

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Chemical Property of methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate

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Technology Process of methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate

There total 4 articles about methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.9%

: 1313377-99-9
methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

: 1364596-14-4
methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate

Guidance literature:: methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)acetate; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 1.16667h;

With N-(benzenesulfonyl)-3-phenyloxaziridine; In tetrahydrofuran; toluene; at -78 ℃; for 0.833333h;

With ammonium chloride; In tetrahydrofuran; water; toluene;

Reference yield:

: 827-41-8
3-phenylpyrazol-5-amine

: 1364596-14-4
methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / xylene / 20 h / Reflux

2.1: trichlorophosphate / 1 h / Reflux

3.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 1.17 h / -78 °C

3.2: 0.83 h / -78 °C

With potassium hexamethylsilazane; trichlorophosphate; toluene-4-sulfonic acid; In tetrahydrofuran; toluene; xylene;

Reference yield:

: 10420-33-4
dimethyl 2-acetylsuccinate

: 1364596-14-4
methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / xylene / 20 h / Reflux

2.1: trichlorophosphate / 1 h / Reflux

3.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 1.17 h / -78 °C

3.2: 0.83 h / -78 °C

With potassium hexamethylsilazane; trichlorophosphate; toluene-4-sulfonic acid; In tetrahydrofuran; toluene; xylene;