(S)-2-{4-[(2-Methoxy-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid

Base Information

• Chemical Name: (S)-2-{4-[(2-Methoxy-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
• CAS No.: 112887-82-8
• Molecular Formula: C₂₅H₂₈N₄O₇
• Molecular Weight: 496.52
• Mol file: 112887-82-8.mol

Synonyms:(S)-2-{4-[(2-Methoxy-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid

Chemical Property of (S)-2-{4-[(2-Methoxy-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{4-[(2-Methoxy-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid

There total 5 articles about (S)-2-{4-[(2-Methoxy-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(S)-2-{4-[(2-Methoxy-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester → (S)-2-{4-[(2-Methoxy-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid (112887-82-8)

Guidance literature:

With sodium hydroxide; In ethanol; for 3h; Ambient temperature;

DOI:10.1021/jm00173a024

Reference yield:

3,4-dihydro-2,6-dimethyl-4-oxoquinazoline (18731-19-6) → (S)-2-{4-[(2-Methoxy-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid (112887-82-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / N-bromosuccinimide (NBS), benzoyl peroxide / CHCl₃ / 6 h / 50 °C / Irradiation

2: 2,6-lutidine / dimethylformamide / 18 h / 80 °C

3: 68 percent / 1 N aq. NaOH / ethanol / 3 h / Ambient temperature

With 2,6-dimethylpyridine; sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; In ethanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jm00173a024

Reference yield:

diethyl N-(p-aminobenzoyl)-L-glutamate (13726-52-8) → (S)-2-{4-[(2-Methoxy-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid (112887-82-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / CaCO₃ / N,N-dimethyl-acetamide / 48 h / 100 °C

2: 2,6-lutidine / dimethylformamide / 18 h / 80 °C

3: 68 percent / 1 N aq. NaOH / ethanol / 3 h / Ambient temperature

With 2,6-dimethylpyridine; sodium hydroxide; calcium carbonate; In ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

DOI:10.1021/jm00173a024

upstream raw materials:

3,4-dihydro-2,6-dimethyl-4-oxoquinazoline

diethyl N-(p-aminobenzoyl)-L-glutamate

diethyl N-<4-<(2-methoxyethyl)amino>benzoyl>-L-glutamate

4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline