Enkephalin, met(2)-pronh2(5)(N(1.5)-glucopyranosyl)

Base Information

Chemical Name:Enkephalin, met(2)-pronh2(5)(N(1.5)-glucopyranosyl)
CAS No.:113282-21-6
Molecular Formula:C₃₆H₅₀N₆O₁₁S
Molecular Weight:774.893
Hs Code.:
DSSTox Substance ID:DTXSID50150342
Wikidata:Q83016397
Mol file:113282-21-6.mol

Synonyms:enkephalin, 2-methionyl-5-prolyl(N(1,5)-glucopyranosyl)amide;enkephalin, Met(2)-ProNH2(5)(N(1.5)-glucopyranosyl);enkephalin,methionyl(2)-prolinamide(5)(N(1,5)-glucopyranosyl);enkephalinamide, Met(2)-Pro(5)N(1,5)-glucopyranose;MPEGA

Suppliers and Price of Enkephalin, met(2)-pronh2(5)(N(1.5)-glucopyranosyl)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Enkephalin, met(2)-pronh2(5)(N(1.5)-glucopyranosyl)

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:1163.8°C at 760 mmHg
PKA:9.97±0.15(Predicted)
Flash Point:657.6°C
PSA：312.37000
Density:1.403g/cm³
LogP:1.25010
XLogP3:-0.4
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:17
Exact Mass:774.32582761
Heavy Atom Count:54
Complexity:1250

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CSCCC(C(=O)NCC(=O)NC(CC1=CC=CC=C1)C(=O)NC(=O)C2CCCN2C3C(C(C(C(O3)CO)O)O)O)NC(=O)C(CC4=CC=C(C=C4)O)N
Isomeric SMILES:CSCC[C@H](C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC(=O)[C@@H]2CCCN2[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)N

Technology Process of Enkephalin, met(2)-pronh2(5)(N(1.5)-glucopyranosyl)

There total 6 articles about Enkephalin, met(2)-pronh2(5)(N(1.5)-glucopyranosyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3068-32-4
1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside

: 113282-21-6,113350-05-3,115729-31-2
(D-Met²,Pro⁵)-enkephalin-N-(galactopyranosyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1: 49 percent / NaN₃ / dimethylformamide / 2 h / 85 - 90 °C

2: 97 percent / H₂ / PtO₂ / ethyl acetate / 1 h

3: 1-hydroxybenzotriazol, 2-mercaptoethanol, dicyclohexylcarbodiimid / tetrahydrofuran / 1) -20 deg C, 1 h, 2) RT, 24 h

4: trifluoroacetic acid / CH₂Cl₂ / 1 h / Ambient temperature

5: NH₃, trifluoroacetic acid / methanol; CH₂Cl₂ / 3 h / Ambient temperature; pH 10-11

With sodium azide; ammonia; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; 2-hydroxyethanethiol; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 13992-26-2
(2R,3S,4S,5R,6R)-2-(acetoxymethyl)-6-azidotetrahydro-2H-pyran-3,4,5-triyl triacetate

: 113282-21-6,113350-05-3,115729-31-2
(D-Met²,Pro⁵)-enkephalin-N-(galactopyranosyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / H₂ / PtO₂ / ethyl acetate / 1 h

2: 1-hydroxybenzotriazol, 2-mercaptoethanol, dicyclohexylcarbodiimid / tetrahydrofuran / 1) -20 deg C, 1 h, 2) RT, 24 h

3: trifluoroacetic acid / CH₂Cl₂ / 1 h / Ambient temperature

4: NH₃, trifluoroacetic acid / methanol; CH₂Cl₂ / 3 h / Ambient temperature; pH 10-11

With ammonia; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; 2-hydroxyethanethiol; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

Reference yield:

: 41355-50-4,51642-81-0,70128-27-7,70145-20-9,94482-21-0,98300-76-6,58484-22-3
2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamine

: 113282-21-6,113350-05-3,115729-31-2
(D-Met²,Pro⁵)-enkephalin-N-(galactopyranosyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxybenzotriazol, 2-mercaptoethanol, dicyclohexylcarbodiimid / tetrahydrofuran / 1) -20 deg C, 1 h, 2) RT, 24 h

2: trifluoroacetic acid / CH₂Cl₂ / 1 h / Ambient temperature

3: NH₃, trifluoroacetic acid / methanol; CH₂Cl₂ / 3 h / Ambient temperature; pH 10-11

With ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; 2-hydroxyethanethiol; In tetrahydrofuran; methanol; dichloromethane;