2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide 2-ethyl-hexanoic acid salt

Base Information

Chemical Name:2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide 2-ethyl-hexanoic acid salt
CAS No.:1196697-64-9
Molecular Formula:C₈H₁₆O₂*C₂₆H₂₃Cl₂F₃N₄O
Molecular Weight:679.61
Hs Code.:

2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide 2-ethyl-hexanoic acid salt

Synonyms:2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide 2-ethyl-hexanoic acid salt

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Chemical Property of 2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide 2-ethyl-hexanoic acid salt

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Technology Process of 2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide 2-ethyl-hexanoic acid salt

There total 7 articles about 2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide 2-ethyl-hexanoic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 149-57-5
2-Ethylhexanoic acid

: 1196696-57-7
2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide

: 1196697-64-9
2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide 2-ethyl-hexanoic acid salt

Guidance literature:: In diethyl ether; at 20 ℃; for 0.5h;

Reference yield:

: 1196698-19-7
3-amino-6-trifluoromethyl-3',6'-dihydro-2'H-[2,4']bipyridinyl-1'-carboxylic acid tert-butyl ester

: 1196697-64-9
2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide 2-ethyl-hexanoic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 20 °C

2.2: Saturated solution

3.1: dichloromethane / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

5.1: diethyl ether / 0.5 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In diethyl ether; ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1196697-64-9
2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide 2-ethyl-hexanoic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 80 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 20 °C

3.2: Saturated solution

4.1: dichloromethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

6.1: diethyl ether / 0.5 h / 20 °C

With potassium phosphate; hydrogen; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile;