2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylfuran-2-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole

Base Information

Chemical Name:2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylfuran-2-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole
CAS No.:1293280-55-3
Molecular Formula:C₂₃H₂₄N₄O₂
Molecular Weight:388.469
Hs Code.:

Synonyms:2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylfuran-2-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole

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Chemical Property of 2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylfuran-2-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole

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Technology Process of 2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylfuran-2-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole

There total 5 articles about 2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylfuran-2-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 169772-63-8
3-phenyl-2-furoic acid

: 1293284-71-5
2-(4,6-dimethyl-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole

: 1293280-55-3
2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylfuran-2-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 86732-22-1
2-benzyloctahydropyrrolo[3,4-c]pyrrole

: 1293280-55-3
2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylfuran-2-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 24 h / 23 °C

2: hydrogen / palladium 10% on activated carbon / acetic acid; methanol / 72 h / 3620.13 Torr

3: caesium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 23 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

With hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 186202-73-3
tert-butyl 5-benzylhexahydropyrrolo[3.4-c]pyrrole-2(1H)-carboxylate

: 1293280-55-3
2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylfuran-2-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / acetic acid; methanol / 72 h / 3620.13 Torr

2: caesium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 23 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

With hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;