(2S,3S)-3-[(S)-3-((R)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-propyl]-2-methyl-2-(3-oxo-butyl)-cyclopentanone

Base Information

• Chemical Name: (2S,3S)-3-[(S)-3-((R)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-propyl]-2-methyl-2-(3-oxo-butyl)-cyclopentanone
• CAS No.: 133201-87-3
• Molecular Formula: C₂₄H₃₇O₃P
• Molecular Weight: 404.53
• Mol file: 133201-87-3.mol

Synonyms:(2S,3S)-3-[(S)-3-((R)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-propyl]-2-methyl-2-(3-oxo-butyl)-cyclopentanone

Chemical Property of (2S,3S)-3-[(S)-3-((R)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-propyl]-2-methyl-2-(3-oxo-butyl)-cyclopentanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-[(S)-3-((R)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-propyl]-2-methyl-2-(3-oxo-butyl)-cyclopentanone

There total 10 articles about (2S,3S)-3-[(S)-3-((R)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-propyl]-2-methyl-2-(3-oxo-butyl)-cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+)-3-<3'-<(S)-tert-butylphenylphosphinoyl>-1'-methylprop-2'-enyl>-2-methyl-2-(3''-oxobut-1''-enyl)cyclopentan-1-one (133201-84-0,133319-26-3) → (2R,3R)-3-[(R)-3-((S)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-propyl]-2-methyl-2-(3-oxo-butyl)-cyclopentanone (133201-87-3)

Guidance literature:

With pyridine; hydrogen; palladium on activated charcoal; In ethyl acetate; under 1650.1 Torr;

DOI:10.1039/c39910000058

Reference yield:

(2S,3S)-3-[(E)-(R)-3-((R)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-allyl]-2-methyl-2-((E)-3-oxo-but-1-enyl)-cyclopentanone (133201-84-0,133319-26-3) → (2S,3S)-3-[(S)-3-((R)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-propyl]-2-methyl-2-(3-oxo-butyl)-cyclopentanone (133201-87-3)

Guidance literature:

With pyridine; hydrogen; palladium on activated charcoal; In ethyl acetate; under 1650.1 Torr;

DOI:10.1039/c39910000058

Reference yield:

2-methyl-2-cyclopenten-1-one (1120-73-6) → (2S,3S)-3-[(S)-3-((R)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-propyl]-2-methyl-2-(3-oxo-butyl)-cyclopentanone (133201-87-3)

Guidance literature:

Multi-step reaction with 2 steps

2: H₂, pyridine / 10percent Pd/C / ethyl acetate / 1650.1 Torr

With pyridine; hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1039/c39910000058

upstream raw materials:

(2S,3S)-3-[(E)-(R)-3-((R)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-allyl]-2-methyl-2-((E)-3-oxo-but-1-enyl)-cyclopentanone

2-methyl-2-cyclopenten-1-one

(R)-tert-butylmethylphenylphosphine oxide

(R_p)-(E)-But-2-enyl-tert-butylphenylphosphine oxide

Downstream raw materials:

(1S,7aS)-1-[(S)-3-((R)-tert-Butyl-phenyl-phosphinoyl)-1-methyl-propyl]-7a-methyl-1,2,3,6,7,7a-hexahydro-inden-5-one