6-Chloro-3-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine

Base Information

• Chemical Name: 6-Chloro-3-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine
• CAS No.: 7190-81-0
• Molecular Formula: C₁₁H₆Cl₂N₄
• Molecular Weight: 265.101
• DSSTox Substance ID: DTXSID501190524
• Nikkaji Number: J2.187.739E
• Mol file: 7190-81-0.mol

Synonyms:7190-81-0;6-chloro-3-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine;6-chloro-3-(4-chlorophenyl)[1,2,4]triazolo[4,3-b]pyridazine;DTXSID501190524;6-chloro-3-(4-chlorophenyl)-1,2,4-triazolo[4,3-b]pyridazine;AKOS001734365;CS-0268192;EU-0019815;EN300-236437;SR-01000538858;SR-01000538858-1;F1967-0574;3-(4-Chlorophenyl)-6-chloro-1,2,4-triazolo[4,3-b]pyridazine;6-Chloro-3-(4-chloro-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine

Chemical Property of 6-Chloro-3-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 263.9969516
• Heavy Atom Count: 17
• Complexity: 270

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=NN=C3N2N=C(C=C3)Cl)Cl

Technology Process of 6-Chloro-3-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine

There total 3 articles about 6-Chloro-3-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-chlorobenzylidene-(6-chloro-3-pyridazinyl)-hydrazine (7190-94-5) → 6-chloro-3-(4'-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine (7190-81-0)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bioorg.2019.01.049

Reference yield: 72.0%

N-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-N'-(6-chloro-pyridazin-3-yl)-hydrazine → 6-chloro-3-(4'-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine (7190-81-0)

Guidance literature:

With copper dichloride; In N,N-dimethyl-formamide; at 50 - 130 ℃; for 1.33333h;

DOI:10.1016/j.tet.2005.01.111

Reference yield:

→ 6-chloro-3-(4'-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine (7190-81-0)

Guidance literature:

(4-Chlor-benzaldehyd)-(6-chlor-pyridazinyl-3-hydrazon) in Eg., Natriumacetat, Br2 in Eg.;

DOI:10.1016/S0040-4020(01)82127-X

upstream raw materials:

3-chlorobenzylidene-(6-chloro-3-pyridazinyl)-hydrazine