(2S,6R)-2-(2-chlorophenyl)-6-(methoxymethyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]piperazine

Base Information

Chemical Name:(2S,6R)-2-(2-chlorophenyl)-6-(methoxymethyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]piperazine
CAS No.:1589599-35-8
Molecular Formula:C₁₉H₂₂ClN₃O₅S
Molecular Weight:439.92
Hs Code.:

Synonyms:(2S,6R)-2-(2-chlorophenyl)-6-(methoxymethyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]piperazine

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Chemical Property of (2S,6R)-2-(2-chlorophenyl)-6-(methoxymethyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]piperazine

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Technology Process of (2S,6R)-2-(2-chlorophenyl)-6-(methoxymethyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]piperazine

There total 7 articles about (2S,6R)-2-(2-chlorophenyl)-6-(methoxymethyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: C₁₉H₂₄ClN₃O₆S

: 1589599-35-8
(2S,6R)-2-(2-chlorophenyl)-6-(methoxymethyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]piperazine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 18h;
DOI:10.1039/c3ob42512f

Reference yield:

: 141315-50-6
(S)-2-amino-(2-chlorophenyl)ethanoic acid

: 1589599-35-8
(2S,6R)-2-(2-chlorophenyl)-6-(methoxymethyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]piperazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / water; 1,4-dioxane / 15 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 96 h / 0 - 70 °C

3.1: thionyl chloride; triethylamine; 1H-imidazole / dichloromethane / -60 - 20 °C

4.1: ruthenium(III) chloride trihydrate; sodium periodate / acetonitrile; water / 2 h / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

5.2: 20 h

6.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h

With 1H-imidazole; sodium periodate; lithium aluminium tetrahydride; thionyl chloride; ruthenium(III) chloride trihydrate; sodium hydride; sodium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob42512f

Reference yield:

: 1213855-02-7
(2S)-2-(2-chlorophenyl)-2-(methylamino)ethan-1-ol

: 1589599-35-8
(2S,6R)-2-(2-chlorophenyl)-6-(methoxymethyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]piperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride; triethylamine; 1H-imidazole / dichloromethane / -60 - 20 °C

2.1: ruthenium(III) chloride trihydrate; sodium periodate / acetonitrile; water / 2 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

3.2: 20 h

4.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h

With 1H-imidazole; sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob42512f