1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylic acid

Base Information

• Chemical Name: 1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylic acid
• CAS No.: 1232333-83-3
• Molecular Formula: C₁₈H₁₄N₄O₃
• Molecular Weight: 334.334

Synonyms:1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylic acid

Chemical Property of 1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of 1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylic acid

There total 1 articles about 1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid ethyl ester (1232333-78-6) → 1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylic acid (1232333-83-3)

Guidance literature:

1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid ethyl ester; With water; lithium hydroxide; In 1,4-dioxane; at 20 ℃;

With hydrogenchloride; In water; pH=1;

Reference yield:

1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylic acid (1232333-83-3) + isopropylamine (75-31-0) → 1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide (1232333-88-8)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

C6H8N2*(x)ClH + 1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylic acid (1232333-83-3) → 1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (pyridin-3-ylmethyl)-amide (1232333-90-2)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

upstream raw materials:

1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid ethyl ester

Downstream raw materials:

1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide

1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (pyridin-3-ylmethyl)-amide

1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]-N-isobutyl-cyclopropanecarboxamide

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