(+)-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)phenyl)methanol

Base Information

Chemical Name:(+)-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)phenyl)methanol
CAS No.:1177258-88-6
Molecular Formula:C₃₉H₅₆O₄Si₂
Molecular Weight:645.042
Hs Code.:

Synonyms:(+)-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)phenyl)methanol

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Chemical Property of (+)-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)phenyl)methanol

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Technology Process of (+)-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)phenyl)methanol

There total 3 articles about (+)-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₁H₅₈O₅Si₂

: 1177258-88-6
(+)-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)phenyl)methanol

Guidance literature:: With methanol; potassium carbonate; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol901437f

Reference yield:

: 18982-54-2
o-bromobenzyl alcohol

: 1177258-88-6
(+)-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / 110 °C / Inert atmosphere; Darkness

3: methanol; potassium carbonate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With methanol; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; toluene; 2: Stille coupling;
DOI:10.1021/ol901437f

Reference yield:

: 82466-12-4
2-bromobenzyl acetate

: 1177258-88-6
(+)-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / 110 °C / Inert atmosphere; Darkness

2: methanol; potassium carbonate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; toluene; 1: Stille coupling;
DOI:10.1021/ol901437f