7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene baccatine VI

Base Information

• Chemical Name: 7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene baccatine VI
• CAS No.: 196404-37-2
• Molecular Formula: C₃₂H₄₂O₉
• Molecular Weight: 570.68

Synonyms:7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene baccatine VI

Chemical Property of 7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene baccatine VI

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene baccatine VI

There total 10 articles about 7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene baccatine VI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene-13-oxo baccatine VI (196404-40-7) → 7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene baccatine VI (196404-37-2)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.5h;

DOI:10.1016/S0040-4020(97)00797-7

Reference yield:

benzaldehyde dimethyl acetal (1125-88-8) → 7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene baccatine VI (196404-37-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 80 percent / p-toluenesulfonic acid / tetrahydrofuran / 7.67 h / 20 - 60 °C / ice cooling

2: 86 percent / aq. NaOH / tetrahydrofuran / 21.5 h / 20 °C / Heating

3: 59 percent / N-methylmorpholine N-oxide / OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 62.5 h

4: 95 percent / imidazole / dimethylformamide / 2.25 h / 20 °C

5: 98 percent / pyridine / 19.5 h / 20 °C / ice cooling

6: 60 percent / tetrabutylammonium acetate / butan-2-one / 14.5 h / Heating

7: 44 percent / pyridine; DMAP / 21 h / 20 °C

8: 48 percent / CuCl₂; tert-BuOOH; 4 Angstroem molecular sieves / toluene; 2,2,4-trimethyl-pentane / 15 h

9: 59 percent / DIBALH / toluene / 0.5 h / -78 °C

With pyridine; 1H-imidazole; tert.-butylhydroperoxide; dmap; sodium hydroxide; 4 A molecular sieve; tetrabutylammonium acetate; diisobutylaluminium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; copper dichloride; osmium(VIII) oxide; In tetrahydrofuran; 2,2,4-trimethylpentane; water; N,N-dimethyl-formamide; toluene; butanone; tert-butyl alcohol; 1: Cyclization / 2: Hydrolysis / 3: dihydroxylation / 4: silylation / 5: mesylation / 6: Cyclization / 7: Acetylation / 8: Oxidation / 9: Reduction;

DOI:10.1016/S0040-4020(97)00797-7

Reference yield:

5-O-cinnamoyl-9,10-isopropylidenetaxicine I (14550-93-7) → 7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene baccatine VI (196404-37-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 80 percent / p-toluenesulfonic acid / tetrahydrofuran / 7.67 h / 20 - 60 °C / ice cooling

2: 86 percent / aq. NaOH / tetrahydrofuran / 21.5 h / 20 °C / Heating

3: 59 percent / N-methylmorpholine N-oxide / OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 62.5 h

4: 95 percent / imidazole / dimethylformamide / 2.25 h / 20 °C

5: 98 percent / pyridine / 19.5 h / 20 °C / ice cooling

6: 60 percent / tetrabutylammonium acetate / butan-2-one / 14.5 h / Heating

7: 44 percent / pyridine; DMAP / 21 h / 20 °C

8: 48 percent / CuCl₂; tert-BuOOH; 4 Angstroem molecular sieves / toluene; 2,2,4-trimethyl-pentane / 15 h

9: 59 percent / DIBALH / toluene / 0.5 h / -78 °C

With pyridine; 1H-imidazole; tert.-butylhydroperoxide; dmap; sodium hydroxide; 4 A molecular sieve; tetrabutylammonium acetate; diisobutylaluminium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; copper dichloride; osmium(VIII) oxide; In tetrahydrofuran; 2,2,4-trimethylpentane; water; N,N-dimethyl-formamide; toluene; butanone; tert-butyl alcohol; 1: Cyclization / 2: Hydrolysis / 3: dihydroxylation / 4: silylation / 5: mesylation / 6: Cyclization / 7: Acetylation / 8: Oxidation / 9: Reduction;

DOI:10.1016/S0040-4020(97)00797-7

upstream raw materials:

7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene-13-oxo baccatine VI

benzaldehyde dimethyl acetal

5-O-cinnamoyl-9,10-isopropylidenetaxicine I

1,2-O-benzylidene-9,10-O-isopropylidene taxicine I

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 196404-37-2 7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene baccatine VI

Send

Send

Metric Ton KG G Pound L ML

Send

Send