(+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one

Base Information

Chemical Name:(+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one
CAS No.:121960-25-6
Molecular Formula:C₂₃H₃₂O₃Si
Molecular Weight:384.591
Hs Code.:

Synonyms:(+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one

Suppliers and Price of (+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one

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Technology Process of (+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one

There total 12 articles about (+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 22627-70-9
3-ethoxycyclopent-2-en-1-one

: 121893-33-2
(+/-)-3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopentene-1-carboxaldehyde

: 121960-25-6
(+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one

: 121893-34-3,121960-25-6
(+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 4h; Yield given;
DOI:10.1016/S0040-4020(01)86640-0

Reference yield: 52.0%

: 22627-70-9
3-ethoxycyclopent-2-en-1-one

: 121893-33-2
(+/-)-3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopentene-1-carboxaldehyde

: 121960-25-6
(+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one

: 121893-34-3,121960-25-6
(+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 4h; Yield given;
DOI:10.1016/S0040-4020(01)86640-0

Reference yield:

: 121893-28-5
(+/-)-2-methyl-1-cyclopentene-1,3-dimethanol

: 121960-25-6
(+/-)-5-<<3-<(dimethylphenylsilyl)methyl>-2-methyl-2-cyclopenten-1-yl>hydroxymethyl>-3-ethoxy-2-cyclopenten-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / pyridine / tetrahydrofuran / 14 h / Ambient temperature

2: 94 percent / tetrahydrofuran / 12 h / -60 °C

3: 87 percent / lithium aluminum hydride / diethyl ether / 1) -45 deg C, 1 h, 2) -45 deg C - room temperature, 3 h

4: 51 percent / chromium trioxide, pyridine / CH₂Cl₂ / 3 h / Ambient temperature

5: n-butyllithium, diisopropylamine / tetrahydrofuran; hexamethylphosphoric acid triamide / 4 h / -78 °C

With pyridine; chromium(VI) oxide; lithium aluminium tetrahydride; n-butyllithium; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(01)86640-0