1-{4-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenyl}ethanone

Base Information

Chemical Name:1-{4-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenyl}ethanone
CAS No.:1235344-39-4
Molecular Formula:C₂₄H₁₉ClN₂O₂
Molecular Weight:402.88
Hs Code.:

Synonyms:1-{4-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenyl}ethanone

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Chemical Property of 1-{4-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenyl}ethanone

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Technology Process of 1-{4-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenyl}ethanone

There total 5 articles about 1-{4-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenyl}ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₂BrClN₂O

: 149104-90-5
4-acetylphenylboronic acid

: 1235344-39-4
1-{4-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenyl}ethanone

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 80 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ol101087j

Reference yield:

: 3815-80-3
3-(p-anisyl)sydnone

: 1235344-39-4
1-{4-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenyl}ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: sodium acetate; Iodine monochloride; acetic acid

2: 5,5-dimethyl-1,3-cyclohexadiene / Reflux

3: sulfuric acid; water / 0.5 h / 180 °C

4: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

5: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; sodium acetate; Iodine monochloride; acetic acid; In 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide; 4: Suzuki cross-coupling reaction / 5: Suzuki cross-coupling reaction;
DOI:10.1002/ejoc.201100119

Reference yield:

: 1235344-12-3
ethyl 3-bromo-5-iodo-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxylate

: 1235344-39-4
1-{4-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenyl}ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; water / 0.5 h / 180 °C

2: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; In water; N,N-dimethyl-formamide; 2: Suzuki cross-coupling reaction / 3: Suzuki cross-coupling reaction;
DOI:10.1002/ejoc.201100119