11α-cyano-1β-hydroxy-1α-(2'-phenylsulfonylethyl)-3α,10α-oxido-2α,13α-oxido-8β,12,12-trimethylbicyclo<6.4.0^3,8>dodecane

Base Information

• Chemical Name: 11α-cyano-1β-hydroxy-1α-(2'-phenylsulfonylethyl)-3α,10α-oxido-2α,13α-oxido-8β,12,12-trimethylbicyclo<6.4.0^3,8>dodecane
• CAS No.: 166534-10-7
• Molecular Formula: C₂₅H₃₃NO₅S
• Molecular Weight: 459.607
• Mol file: 166534-10-7.mol

Synonyms:11α-cyano-1β-hydroxy-1α-(2'-phenylsulfonylethyl)-3α,10α-oxido-2α,13α-oxido-8β,12,12-trimethylbicyclo<6.4.0^3,8>dodecane

Chemical Property of 11α-cyano-1β-hydroxy-1α-(2'-phenylsulfonylethyl)-3α,10α-oxido-2α,13α-oxido-8β,12,12-trimethylbicyclo<6.4.0^3,8>dodecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11α-cyano-1β-hydroxy-1α-(2'-phenylsulfonylethyl)-3α,10α-oxido-2α,13α-oxido-8β,12,12-trimethylbicyclo<6.4.0^3,8>dodecane

There total 2 articles about 11α-cyano-1β-hydroxy-1α-(2'-phenylsulfonylethyl)-3α,10α-oxido-2α,13α-oxido-8β,12,12-trimethylbicyclo<6.4.0^3,8>dodecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1S,2R,6S,8R,9R,11S)-11-(2-Benzenesulfonyl-ethyl)-11-hydroxy-6,10,10-trimethyl-12-oxo-2-triisopropylsilanyloxymethyl-13-oxa-tricyclo[6.4.1.01,6]tridecane-9-carbonitrile (185013-20-1) → 11α-cyano-1β-hydroxy-1α-(2'-phenylsulfonylethyl)-3α,10α-oxido-2α,13α-oxido-8β,12,12-trimethylbicyclo<6.4.03,8>dodecane (166534-10-7)

Guidance literature:

With sodium cyanoborohydride; trifluoroacetic acid; at 0 ℃; for 0.25h;

DOI:10.1016/0040-4020(96)00866-6

Reference yield: 90.0%

(1S,2R,6S,8R,9R,11S)-11-(2-Benzenesulfonyl-ethyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-11-hydroxy-6,10,10-trimethyl-12-oxo-13-oxa-tricyclo[6.4.1.01,6]tridecane-9-carbonitrile → 11α-cyano-1β-hydroxy-1α-(2'-phenylsulfonylethyl)-3α,10α-oxido-2α,13α-oxido-8β,12,12-trimethylbicyclo<6.4.03,8>dodecane (166534-10-7)

Guidance literature:

With sodium cyanoborohydride; In trifluoroacetic acid; at 0 ℃;

DOI:10.1016/00404-0399(50)1084U-

Reference yield:

11α-cyano-1β-hydroxy-1α-(2'-phenylsulfonylethyl)-3α,10α-oxido-2α,13α-oxido-8β,12,12-trimethylbicyclo<6.4.03,8>dodecane (166534-10-7) → C25H34O6S

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;

DOI:10.1016/00404-0399(50)1084U-

upstream raw materials:

(1S,2R,6S,8R,9R,11S)-11-(2-Benzenesulfonyl-ethyl)-11-hydroxy-6,10,10-trimethyl-12-oxo-2-triisopropylsilanyloxymethyl-13-oxa-tricyclo[6.4.1.0^1,6]tridecane-9-carbonitrile

Downstream raw materials:

1β-hydroxy-2,4Hβ-13-phenylsulfonyl-11,12-dihydro-3α,10α-oxido-2α,20α-oxido-12-nortaxane-12-one

methyl 1β-hydroxy-1α-(2'-phenylsulfonylethyl)-3α,10α-oxido-2α,13α-oxido-8β,12,12-trimethylbicyclo<6.4.0^3,8>dodec-11α-oate