methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate

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Chemical Name:methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate
CAS No.:1093864-75-5
Molecular Formula:C₂₇H₃₆ClN₃O₅
Molecular Weight:518.053
Hs Code.:

Synonyms:methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate

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Chemical Property of methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate

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Technology Process of methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate

There total 33 articles about methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1093865-45-2
methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate

: 1093864-75-5
methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate

Guidance literature:: methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate; With hydrogenchloride; In 1,4-dioxane; acetonitrile;

With sodium hydroxide; In water; ethyl acetate;

Reference yield:

: 942144-43-6,942144-42-5
tert-butyl (S)-1-hydroxy-3-((R)-tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamate

: 1093864-75-5
methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 16 h / 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 1.5 h / 80 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 12 h / -78 - 0 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 2068.65 Torr

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

6.1: hydrogenchloride / 1,4-dioxane; acetonitrile

With pyridine; hydrogenchloride; sodium azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 942144-12-9
tert-butyl (2S,4R)-1-hydroxy-4-(hydroxymethyl)hept-6-en-2-ylcarbamate

: 1093864-75-5
methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate

Guidance literature:: Multi-step reaction with 12 steps

1.1: toluene-4-sulfonic acid / acetone / 1 h / -20 - 20 °C

1.2: 0.08 h / 20 °C

2.1: 1H-imidazole / dmap / dichloromethane / 20 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 0 °C

3.2: 16 h / 20 °C

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5.1: tetraethylammonium fluoride / tetrahydrofuran; water / Heating / reflux

6.1: toluene-4-sulfonic acid / methanol / 12 h / 20 °C

6.2: 0.5 h

7.1: pyridine / dichloromethane / 16 h / 20 °C

8.1: sodium azide / N,N-dimethyl-formamide / 1.5 h / 80 °C

9.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

9.2: 12 h / -78 - 0 °C

10.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 2068.65 Torr

11.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

12.1: hydrogenchloride / 1,4-dioxane; acetonitrile

With pyridine; 1H-imidazole; hydrogenchloride; sodium azide; dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; tetraethylammonium fluoride; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; dmap; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;