Technology Process of 3-(2-amino-6-o-tolylquinolin-3-yl)-N-cyclohexyl-N-methylpropanamide
There total 17 articles about 3-(2-amino-6-o-tolylquinolin-3-yl)-N-cyclohexyl-N-methylpropanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
for 0.333333h;
Reflux;
Inert atmosphere;
DOI:10.1021/jm200544q
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thionyl chloride / 1 h / 80 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h
3: hydrogen / palladium 10% on activated carbon / methanol / 0.5 h / 2585.81 Torr
4: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.17 h / Reflux
5: p-toluenesulfonylanhydride / α,α,α-trifluorotoluene / 0.17 h / Reflux
6: trifluoroacetic acid / Reflux
With
thionyl chloride; p-toluenesulfonylanhydride; hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
palladium 10% on activated carbon;
In
methanol; dichloromethane; chloroform; α,α,α-trifluorotoluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h
2: hydrogen / palladium 10% on activated carbon / methanol / 0.5 h / 2585.81 Torr
3: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.17 h / Reflux
4: p-toluenesulfonylanhydride / α,α,α-trifluorotoluene / 0.17 h / Reflux
5: trifluoroacetic acid / Reflux
With
p-toluenesulfonylanhydride; hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
palladium 10% on activated carbon;
In
methanol; dichloromethane; chloroform; α,α,α-trifluorotoluene;
