3,3-bis-(4-methylphenyl)oxirane-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 3,3-bis-(4-methylphenyl)oxirane-2-carboxylic acid methyl ester
• CAS No.: 243118-84-5
• Molecular Formula: C₁₈H₁₈O₃
• Molecular Weight: 282.339
• Mol file: 243118-84-5.mol

Synonyms:3,3-bis-(4-methylphenyl)oxirane-2-carboxylic acid methyl ester

Chemical Property of 3,3-bis-(4-methylphenyl)oxirane-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3,3-bis-(4-methylphenyl)oxirane-2-carboxylic acid methyl ester

There total 1 articles about 3,3-bis-(4-methylphenyl)oxirane-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(p-methylphenyl)-methanone (611-97-2) + methyl chloroacetate (96-34-4) → 3,3-bis-(4-methylphenyl)oxirane-2-carboxylic acid methyl ester (243118-84-5)

Guidance literature:

With sodium methylate; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/jm960274q

Reference yield:

3,3-bis-(4-methylphenyl)oxirane-2-carboxylic acid methyl ester (243118-84-5) → 3-<2-(4-methoxyphenyl)ethoxy>-2-<(4-methoxy-5,6-dihydrofuro<2,3-d>pyrimidin-2-yl)oxy>-3,3-bis(4-methylphenyl)propionic acid

Guidance literature:

Multi-step reaction with 3 steps

1: BF₃*Et₂O / CH₂Cl₂ / 2 h / Ambient temperature

2: 1 N aq. NaOH / dioxane / 2 h / 80 °C

3: LiNH₂ / dimethylformamide / 18 h / Ambient temperature

With sodium hydroxide; lithium amide; boron trifluoride diethyl etherate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm9910425

Reference yield:

3,3-bis-(4-methylphenyl)oxirane-2-carboxylic acid methyl ester (243118-84-5) → 2-hydroxy-3-[2-(4-methoxy-phenyl)-ethoxy]-3,3-di-p-tolyl-propionic acid (1025826-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: BF₃*Et₂O / CH₂Cl₂ / 2 h / Ambient temperature

2: 1 N aq. NaOH / dioxane / 2 h / 80 °C

With sodium hydroxide; boron trifluoride diethyl etherate; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm9910425

upstream raw materials:

bis(p-methylphenyl)-methanone

methyl chloroacetate

Downstream raw materials:

2-hydroxy-3-[2-(4-methoxy-phenyl)-ethoxy]-3,3-di-p-tolyl-propionic acid

2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-di-p-tolyl-propionic acid methyl ester