Methyl 7-[3-(4-(2-trifluoromethylsulfonyloxy-1-oxoethyl)-3-methoxy-2-propylphenoxy)propoxy]-3, 4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

Base Information

Chemical Name:Methyl 7-[3-(4-(2-trifluoromethylsulfonyloxy-1-oxoethyl)-3-methoxy-2-propylphenoxy)propoxy]-3, 4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate
CAS No.:138828-22-5
Molecular Formula:C₃₀H₃₇F₃O₁₀S
Molecular Weight:646.679
Hs Code.:

Methyl 7-[3-(4-(2-trifluoromethylsulfonyloxy-1-oxoethyl)-3-methoxy-2-propylphenoxy)propoxy]-3, 4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

Synonyms:Methyl 7-[3-(4-(2-trifluoromethylsulfonyloxy-1-oxoethyl)-3-methoxy-2-propylphenoxy)propoxy]-3, 4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

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Chemical Property of Methyl 7-[3-(4-(2-trifluoromethylsulfonyloxy-1-oxoethyl)-3-methoxy-2-propylphenoxy)propoxy]-3, 4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

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Technology Process of Methyl 7-[3-(4-(2-trifluoromethylsulfonyloxy-1-oxoethyl)-3-methoxy-2-propylphenoxy)propoxy]-3, 4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

There total 5 articles about Methyl 7-[3-(4-(2-trifluoromethylsulfonyloxy-1-oxoethyl)-3-methoxy-2-propylphenoxy)propoxy]-3, 4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 138828-21-4
methyl 7-<3-<4-(2-hydroxy-1-oxoethyl)-3-methoxy-2-propylphenoxy>propoxy>-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

: 138828-22-5
Methyl 7-[3-(4-(2-trifluoromethylsulfonyloxy-1-oxoethyl)-3-methoxy-2-propylphenoxy)propoxy]-3, 4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 0.75h;
DOI:10.1021/jm00006a002

Reference yield:

: 120072-58-4
methyl ester of 7-<3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy>-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid

: 138828-22-5
Methyl 7-[3-(4-(2-trifluoromethylsulfonyloxy-1-oxoethyl)-3-methoxy-2-propylphenoxy)propoxy]-3, 4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 15 min, 2.) THF, 0 deg C, 15 min

2: m-chloroperoxybenzoic acid, NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

3: p-TsOH / diethyl ether / 1.5 h / 25 °C

4: 2,6-lutidine / CH₂Cl₂ / 0.75 h / -78 °C

With 2,6-dimethylpyridine; sodium hydrogencarbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In diethyl ether; dichloromethane;
DOI:10.1021/jm00006a002

Reference yield:

: 7-{3-[3-Methoxy-2-propyl-4-(1-trimethylsilanyloxy-vinyl)-phenoxy]-propoxy}-8-propyl-chroman-2-carboxylic acid methyl ester

: 138828-22-5
Methyl 7-[3-(4-(2-trifluoromethylsulfonyloxy-1-oxoethyl)-3-methoxy-2-propylphenoxy)propoxy]-3, 4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: m-chloroperoxybenzoic acid, NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

2: p-TsOH / diethyl ether / 1.5 h / 25 °C

3: 2,6-lutidine / CH₂Cl₂ / 0.75 h / -78 °C

With 2,6-dimethylpyridine; sodium hydrogencarbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; dichloromethane;
DOI:10.1021/jm00006a002