C₁₂H₁₃NO₃

Base Information

• Chemical Name: C₁₂H₁₃NO₃
• CAS No.: 1159252-68-2
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.24
• Mol file: 1159252-68-2.mol

Synonyms:C₁₂H₁₃NO₃

Chemical Property of C₁₂H₁₃NO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₃NO₃

There total 4 articles about C₁₂H₁₃NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H17NO3 → C12H13NO3 (1159252-68-2)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 100 ℃; Inert atmosphere;

DOI:10.1021/jacs.1c01100

Reference yield:

3-Phenyl-2-oxo-3-pyrrolidincarbonsaeure-ethylester (79232-58-9) → C12H13NO3 (1159252-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 100 °C / Inert atmosphere

With water; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; mineral oil;

DOI:10.1021/jacs.1c01100

Reference yield:

diethyl 2-phenylmalonate (83-13-6) → C12H13NO3 (1159252-68-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere

1.2: 60 °C / Inert atmosphere

2.1: sodium tetrahydroborate; cobalt(II) chloride hexahydrate; methanol / 0 - 23 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol / 100 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; cobalt(II) chloride hexahydrate; water; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; mineral oil;

DOI:10.1021/jacs.1c01100

upstream raw materials:

3-Phenyl-2-oxo-3-pyrrolidincarbonsaeure-ethylester

diethyl 2-phenylmalonate

diethyl (2-cyanomethyl)-2-phenylpropanedioate

Downstream raw materials:

1-methyl-3-phenylpyrrolidin-2-one