(S,E)-methyl 2-(3-(benzo[d][1,3]dioxol-5-yl)-N-benzylacrylamido)-3-(5-hydroxy-1-tosyl-1H-indol-3-yl)propanoate

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Chemical Name:(S,E)-methyl 2-(3-(benzo[d][1,3]dioxol-5-yl)-N-benzylacrylamido)-3-(5-hydroxy-1-tosyl-1H-indol-3-yl)propanoate
CAS No.:1333380-16-7
Molecular Formula:C₃₆H₃₂N₂O₈S
Molecular Weight:652.725
Hs Code.:

Synonyms:(S,E)-methyl 2-(3-(benzo[d][1,3]dioxol-5-yl)-N-benzylacrylamido)-3-(5-hydroxy-1-tosyl-1H-indol-3-yl)propanoate

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Chemical Property of (S,E)-methyl 2-(3-(benzo[d][1,3]dioxol-5-yl)-N-benzylacrylamido)-3-(5-hydroxy-1-tosyl-1H-indol-3-yl)propanoate

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Technology Process of (S,E)-methyl 2-(3-(benzo[d][1,3]dioxol-5-yl)-N-benzylacrylamido)-3-(5-hydroxy-1-tosyl-1H-indol-3-yl)propanoate

There total 9 articles about (S,E)-methyl 2-(3-(benzo[d][1,3]dioxol-5-yl)-N-benzylacrylamido)-3-(5-hydroxy-1-tosyl-1H-indol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1333380-15-6
C₅₂H₅₀N₂O₈SSi

: 1333380-16-7
(S,E)-methyl 2-(3-(benzo[d][1,3]dioxol-5-yl)-N-benzylacrylamido)-3-(5-hydroxy-1-tosyl-1H-indol-3-yl)propanoate

Guidance literature:: With tetrabutyl ammonium fluoride;
DOI:10.1021/ol2021669

Reference yield:

: 1333380-12-3
methyl (S)-2-amino-3-(5-((tert-butyldiphenylsilyl)oxy)-1H-indol-3-yl)propanoate

: 1333380-16-7
(S,E)-methyl 2-(3-(benzo[d][1,3]dioxol-5-yl)-N-benzylacrylamido)-3-(5-hydroxy-1-tosyl-1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium cyanoborohydride

2: potassium carbonate / toluene / 90 °C

3: sodium hydroxide

4: tetrabutyl ammonium fluoride

With tetrabutyl ammonium fluoride; sodium cyanoborohydride; potassium carbonate; sodium hydroxide; In toluene;
DOI:10.1021/ol2021669

Reference yield:

: 1333380-13-4
C₃₅H₃₈N₂O₃Si

: 1333380-16-7
(S,E)-methyl 2-(3-(benzo[d][1,3]dioxol-5-yl)-N-benzylacrylamido)-3-(5-hydroxy-1-tosyl-1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / toluene / 90 °C

2: sodium hydroxide

3: tetrabutyl ammonium fluoride

With tetrabutyl ammonium fluoride; potassium carbonate; sodium hydroxide; In toluene;
DOI:10.1021/ol2021669