Technology Process of 3-(4-((4-fluoropiperidin-1-yl)methyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine-6-carbonitrile
There total 11 articles about 3-(4-((4-fluoropiperidin-1-yl)methyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine-6-carbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / tetrahydrofuran / 16 h / 20 °C
2: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / water; 1,2-dimethoxyethane / 0.5 h / 140 °C / Microwave irradiation
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 55 °C
With
bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; caesium carbonate; triethylamine;
In
tetrahydrofuran; 1,2-dimethoxyethane; water;
2: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.5b00464
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / tetrahydrofuran / 16 h / 20 °C
2: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / water; 1,2-dimethoxyethane / 0.5 h / 140 °C / Microwave irradiation
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 55 °C
With
bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; caesium carbonate; triethylamine;
In
tetrahydrofuran; 1,2-dimethoxyethane; water;
2: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.5b00464
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
1.2: 0 - 20 °C
2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; dimethyl sulfoxide / 18 h / 120 °C / Sealed tube; Inert atmosphere
3.1: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / water; 1,2-dimethoxyethane / 0.5 h / 140 °C / Microwave irradiation
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 55 °C
With
bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutyl ammonium fluoride; potassium acetate; caesium carbonate; sodium iodide;
In
tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
3.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.5b00464
