ethyl (2Z,4R)-5-tert-butyldiphenylsilyloxy-4-ethyl-2-methyl-2-pentenoate

Base Information

Chemical Name:ethyl (2Z,4R)-5-tert-butyldiphenylsilyloxy-4-ethyl-2-methyl-2-pentenoate
CAS No.:1092070-55-7
Molecular Formula:C₂₆H₃₆O₃Si
Molecular Weight:424.656
Hs Code.:

Synonyms:ethyl (2Z,4R)-5-tert-butyldiphenylsilyloxy-4-ethyl-2-methyl-2-pentenoate

Suppliers and Price of ethyl (2Z,4R)-5-tert-butyldiphenylsilyloxy-4-ethyl-2-methyl-2-pentenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (2Z,4R)-5-tert-butyldiphenylsilyloxy-4-ethyl-2-methyl-2-pentenoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (2Z,4R)-5-tert-butyldiphenylsilyloxy-4-ethyl-2-methyl-2-pentenoate

There total 4 articles about ethyl (2Z,4R)-5-tert-butyldiphenylsilyloxy-4-ethyl-2-methyl-2-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 107905-52-2
ethyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate

: 339533-79-8
(2S)-2-ethyl-3-[(tert-butyldiphenylsilyl)oxy]propanal

: 1092070-55-7
ethyl (2Z,4R)-5-tert-butyldiphenylsilyloxy-4-ethyl-2-methyl-2-pentenoate

Guidance literature:: ethyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate; With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

(2S)-2-ethyl-3-[(tert-butyldiphenylsilyl)oxy]propanal; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol8019132

Reference yield:

: (4S)-N-[(R)-2-ethyl-3,3-dimethoxypropanoyl]-4-isopropyl-1,3-thiazolidine-2-thione

: 1092070-55-7
ethyl (2Z,4R)-5-tert-butyldiphenylsilyloxy-4-ethyl-2-methyl-2-pentenoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium borohydride / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

3.1: silica gel; oxalic acid / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

4.1: potassium hexamethylsilazane; 18-crown-6 ether / tetrahydrofuran / 0.25 h / -78 - 20 °C / Inert atmosphere

4.2: 2 h / -78 °C / Inert atmosphere

With 1H-imidazole; lithium borohydride; 18-crown-6 ether; oxalic acid; silica gel; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/acs.orglett.6b01428

Reference yield:

: (S)-3-tert-butyldiphenylsilyloxy-2-ethylpropanal dimethyl acetal

: 1092070-55-7
ethyl (2Z,4R)-5-tert-butyldiphenylsilyloxy-4-ethyl-2-methyl-2-pentenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: silica gel; oxalic acid / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

2.1: potassium hexamethylsilazane; 18-crown-6 ether / tetrahydrofuran / 0.25 h / -78 - 20 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

With 18-crown-6 ether; oxalic acid; silica gel; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/acs.orglett.6b01428