5-(4-acetyl[1,4]diazepan-1-yl)-2-methylpentanoic acid [5-(4-methoxyphenyl)-2H-pyrazol-3-yl]amide

Base Information

Chemical Name:5-(4-acetyl[1,4]diazepan-1-yl)-2-methylpentanoic acid [5-(4-methoxyphenyl)-2H-pyrazol-3-yl]amide
CAS No.:1040718-72-6
Molecular Formula:C₂₃H₃₃N₅O₃
Molecular Weight:427.547
Hs Code.:

Synonyms:5-(4-acetyl[1,4]diazepan-1-yl)-2-methylpentanoic acid [5-(4-methoxyphenyl)-2H-pyrazol-3-yl]amide

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Chemical Property of 5-(4-acetyl[1,4]diazepan-1-yl)-2-methylpentanoic acid [5-(4-methoxyphenyl)-2H-pyrazol-3-yl]amide

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Technology Process of 5-(4-acetyl[1,4]diazepan-1-yl)-2-methylpentanoic acid [5-(4-methoxyphenyl)-2H-pyrazol-3-yl]amide

There total 7 articles about 5-(4-acetyl[1,4]diazepan-1-yl)-2-methylpentanoic acid [5-(4-methoxyphenyl)-2H-pyrazol-3-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1040724-82-0
5-[5-(4-acetyl[1,4]diazepan-1-yl)-2-methylpentanoylamino]-3-(4-methoxyphenyl)pyrazole-1-carboxylic acid tert-butyl ester

: 1040718-72-6
5-(4-acetyl[1,4]diazepan-1-yl)-2-methylpentanoic acid [5-(4-methoxyphenyl)-2H-pyrazol-3-yl]amide

Guidance literature:: 5-[5-(4-acetyl[1,4]diazepan-1-yl)-2-methylpentanoylamino]-3-(4-methoxyphenyl)pyrazole-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 6h;

With water; sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1040724-80-8
dimethyl 2-(3-bromopropyl)-2-methylmalonate

: 1040718-72-6
5-(4-acetyl[1,4]diazepan-1-yl)-2-methylpentanoic acid [5-(4-methoxyphenyl)-2H-pyrazol-3-yl]amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide / water / 24 h / 110 °C

2.1: oxalyl dichloride / dichloromethane / 2 h / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 39 h / 20 - 50 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

With hydrogenchloride; oxalyl dichloride; hydrogen bromide; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jm300247y

Reference yield:

: 1040724-79-5
5-amino-3-(4-methoxyphenyl)pyrazole-1-carboxylic acid tert-butyl ester

: 1040718-72-6
5-(4-acetyl[1,4]diazepan-1-yl)-2-methylpentanoic acid [5-(4-methoxyphenyl)-2H-pyrazol-3-yl]amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane / 2 h / Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 39 h / 20 - 50 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

With hydrogenchloride; oxalyl dichloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm300247y