Chemical Property of Reversine
Chemical Property:
- Vapor Pressure:1.5E-21mmHg at 25°C
- Melting Point:305℃ (decomposition)
- Boiling Point:736.4°Cat760mmHg
- PKA:10.51±0.10(Predicted)
- Flash Point:399.2°C
- PSA：90.99000
- Density:1.343g/cm3
- LogP:3.88870
- Storage Temp.:2-8°C
- Solubility.:DMSO: 7 mg/mL, soluble
- XLogP3:3.9
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:5
- Exact Mass:393.22770851
- Heavy Atom Count:29
- Complexity:503
- Purity/Quality:
-
99%, *data from raw suppliers
Reversine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5
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Description
Reversine is a 2,6-disubstituted purine derivative that was originally found to induce dedifferentiation of C2C12 culture myoblast cells into stem cell progenitors when used at a concentration of 5 μM for four days. Depending on cell type, reversine promotes either differentiation or dedifferentiation. For example, in NT2 neuronal and HL-60 human promyelocytic leukemia cells, it induces differentiation. It inhibits the Aurora A, B, and C kinases with IC50 values of 98-876 nM and acts as an antagonist at the adenosine A3 receptor with a Ki value of 0.66 μM. Reversine is also used for studies of chromosome segregation. It inhibits the mitotic spindle checkpoint enzyme MPS1 with IC50 values of 6 and 2.8 nM for its kinase domain and full-length version, respectively). Reversine induces autophagy in WRO human follicular thyroid cancer cells and decreases Akt/mTOR signaling.
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Uses
Reversine acts as a potent human A3 adenosine receptor antagonist and pan-aurora A/B/C kinase inhibitor. Used for stem cell differentiation.
