26-homo-1,25-dihydroxyvitamin D3

Base Information

• Chemical Name: 26-homo-1,25-dihydroxyvitamin D3
• CAS No.: 105687-81-8
• Molecular Formula: C₂₈H₄₆O₃
• Molecular Weight: 430.671
• Mol file: 105687-81-8.mol

Synonyms:27-Nor-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol,25-ethyl-, (1a,3b,5Z,7E)- (9CI);26-Homo-1,25-dihydroxyvitamin D3; 26-Homo-1a,25-dihydroxyvitamin D3

Chemical Property of 26-homo-1,25-dihydroxyvitamin D3

Chemical Property:

• Vapor Pressure: 1.2E-15mmHg at 25°C
• Boiling Point: 575.6°Cat760mmHg
• Flash Point: 240.5°C
• PSA: 60.69000
• Density: 1.05g/cm³
• LogP: 6.09480

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 26-Homo-1,25-dihydroxyvitamin D3 is an analogs of the hormonal form of vitamin D with leukemia inhibiting properties.

Technology Process of 26-homo-1,25-dihydroxyvitamin D3

There total 11 articles about 26-homo-1,25-dihydroxyvitamin D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(22E,25ξ)-26-homocholesta-5,22-dien-1α,3β,25-triol (103732-12-3) → 26-homo-1.25-(OH)2D3 (105687-81-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / pyridine / 16 h / Ambient temperature

2: 85 percent / hydrogen / 10percent Pd-C / ethyl acetate / 3 h / Ambient temperature

4: 1.) benzene, ethanol, irradiation, 0 deg C, 2.5 min; 2.) reflux, 1 h

With hydrogen; palladium on activated charcoal; In pyridine; ethyl acetate;

DOI:10.1248/cpb.34.4508

Reference yield:

1α,3β-bis(methoxymethoxy)chola-5,23-dien-22-ol (99741-49-8) → 26-homo-1.25-(OH)2D3 (105687-81-8)

Guidance literature:

Multi-step reaction with 10 steps

1: 97 percent / propionic acid / toluene / 2 h / Heating

2: 1.) lithium diisopropylamine; 2.) triethylphosphite, oxygen / 1.) THF, -78 deg C, 30 min

3: lithium aluminium hydride / tetrahydrofuran / 0.5 h / Ambient temperature

4: pyridine / 0.5 h / Ambient temperature

5: lithium aluminium hydride / tetrahydrofuran / 0.5 h / Heating

6: 98 percent / 6 M HCl / tetrahydrofuran / 2.5 h / 50 °C

7: 85 percent / pyridine / 16 h / Ambient temperature

8: 85 percent / hydrogen / 10percent Pd-C / ethyl acetate / 3 h / Ambient temperature

10: 1.) benzene, ethanol, irradiation, 0 deg C, 2.5 min; 2.) reflux, 1 h

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; oxygen; propionic acid; lithium diisopropyl amide; triethyl phosphite; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethyl acetate; toluene;

DOI:10.1248/cpb.34.4508

Reference yield:

(22E,25ξ)-1α,3β-bis(methoxymethoxy)-26-homocholesta-5,22-dien-25-ol (103732-11-2) → 26-homo-1.25-(OH)2D3 (105687-81-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / 6 M HCl / tetrahydrofuran / 2.5 h / 50 °C

2: 85 percent / pyridine / 16 h / Ambient temperature

3: 85 percent / hydrogen / 10percent Pd-C / ethyl acetate / 3 h / Ambient temperature

5: 1.) benzene, ethanol, irradiation, 0 deg C, 2.5 min; 2.) reflux, 1 h

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethyl acetate;

DOI:10.1248/cpb.34.4508

upstream raw materials:

(25ξ)-26-homocholesta-5,7-diene-1α,3β,25-triol

(22E,25ξ)-26-homocholesta-5,22-dien-1α,3β,25-triol

1α,3β-bis(methoxymethoxy)chola-5,23-dien-22-ol

(22E,25ξ)-1α,3β-bis(methoxymethoxy)-26-homocholesta-5,22-dien-25-ol

Refernces