2-{[1-phenyl-3-(4-nitrophenyl)pyrazol-4-yl]methylenehydrazono}-1,3-thiazolidin-4-one-5-yl-acetic acid

Base Information

Chemical Name:2-{[1-phenyl-3-(4-nitrophenyl)pyrazol-4-yl]methylenehydrazono}-1,3-thiazolidin-4-one-5-yl-acetic acid
CAS No.:1610618-64-8
Molecular Formula:C₂₁H₁₆N₆O₅S
Molecular Weight:464.461
Hs Code.:

Synonyms:2-{[1-phenyl-3-(4-nitrophenyl)pyrazol-4-yl]methylenehydrazono}-1,3-thiazolidin-4-one-5-yl-acetic acid

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Chemical Property of 2-{[1-phenyl-3-(4-nitrophenyl)pyrazol-4-yl]methylenehydrazono}-1,3-thiazolidin-4-one-5-yl-acetic acid

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Technology Process of 2-{[1-phenyl-3-(4-nitrophenyl)pyrazol-4-yl]methylenehydrazono}-1,3-thiazolidin-4-one-5-yl-acetic acid

There total 3 articles about 2-{[1-phenyl-3-(4-nitrophenyl)pyrazol-4-yl]methylenehydrazono}-1,3-thiazolidin-4-one-5-yl-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 108-31-6
maleic anhydride

: 1160166-02-8
1-((3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiosemicarbazide

: 1610618-64-8
2-{[1-phenyl-3-(4-nitrophenyl)pyrazol-4-yl]methylenehydrazono}-1,3-thiazolidin-4-one-5-yl-acetic acid

Guidance literature:: In toluene; for 3h; Reflux;
DOI:10.1016/j.bmcl.2014.04.064

Reference yield: 78.0%

: 108-31-6
maleic anhydride

: 21487-49-0
3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

: 79-19-6
thiosemicarbazide

: 1610618-64-8
2-{[1-phenyl-3-(4-nitrophenyl)pyrazol-4-yl]methylenehydrazono}-1,3-thiazolidin-4-one-5-yl-acetic acid

Guidance literature:: With sonicated baker’s yeast; In acetonitrile; at 20 ℃; for 8h; Microbiological reaction; Green chemistry; Enzymatic reaction;
DOI:10.1515/hc-2017-0130

Reference yield:

: 21487-49-0
3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

: 1610618-64-8
2-{[1-phenyl-3-(4-nitrophenyl)pyrazol-4-yl]methylenehydrazono}-1,3-thiazolidin-4-one-5-yl-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 1 h / Reflux; Molecular sieve

2: toluene / 3 h / Reflux

In ethanol; toluene; 2: |Michael Addition;
DOI:10.1016/j.bmcl.2014.04.064