6-[(3S,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one oxime

Base Information

Chemical Name:6-[(3S,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one oxime
CAS No.:310882-29-2
Molecular Formula:C₂₀H₂₆F₂N₄O₂
Molecular Weight:392.449
Hs Code.:

Synonyms:6-[(3S,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one oxime

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Chemical Property of 6-[(3S,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one oxime

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Technology Process of 6-[(3S,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one oxime

There total 5 articles about 6-[(3S,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58009-93-1
3-methyl-2-oxo-butylphosphonic acid dimethyl ester

: 310882-29-2
6-[(3S,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one oxime

Guidance literature:: Multi-step reaction with 3 steps

1: 90.9 percent / 1,8-diazabicyclo[5,4,0]undecen-7-ene; LiCl / acetonitrile / 3 h / 20 °C

2: 81 percent / H₂ / Pd/C / ethanol / 20 °C

3: 82.3 percent / NH₂OH*HCl; pyridine / ethanol / 20 °C

With pyridine; 1,8-diazabicyclo[5.4.0]-undecen-7-ene; hydroxylamine hydrochloride; hydrogen; lithium chloride; palladium on activated charcoal; In ethanol; acetonitrile; 1: Horner-Wadsworth-Emmons reaction / 2: Catalytic hydrogenation / 3: Condensation;
DOI:10.1016/S0968-0896(00)00177-2

Reference yield:

: 149809-43-8
(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

: 310882-29-2
6-[(3S,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one oxime

Guidance literature:: Multi-step reaction with 5 steps

1: 84.5 percent / dimethylsulfoxide / 15 h / 55 °C

2: 52.1 percent / diisobutylaluminum hydride / toluene / -78 - 20 °C

3: 90.9 percent / 1,8-diazabicyclo[5,4,0]undecen-7-ene; LiCl / acetonitrile / 3 h / 20 °C

4: 81 percent / H₂ / Pd/C / ethanol / 20 °C

5: 82.3 percent / NH₂OH*HCl; pyridine / ethanol / 20 °C

With pyridine; 1,8-diazabicyclo[5.4.0]-undecen-7-ene; hydroxylamine hydrochloride; hydrogen; diisobutylaluminium hydride; lithium chloride; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; toluene; acetonitrile; 1: Substitution / 2: Reduction / 3: Horner-Wadsworth-Emmons reaction / 4: Catalytic hydrogenation / 5: Condensation;
DOI:10.1016/S0968-0896(00)00177-2

Reference yield:

: 310882-12-3
(2R-cis)-2-(2,4-difluorophenyl)-4-formylmethyl-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

: 310882-29-2
6-[(3S,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one oxime

Guidance literature:: Multi-step reaction with 3 steps

1: 90.9 percent / 1,8-diazabicyclo[5,4,0]undecen-7-ene; LiCl / acetonitrile / 3 h / 20 °C

2: 81 percent / H₂ / Pd/C / ethanol / 20 °C

3: 82.3 percent / NH₂OH*HCl; pyridine / ethanol / 20 °C

With pyridine; 1,8-diazabicyclo[5.4.0]-undecen-7-ene; hydroxylamine hydrochloride; hydrogen; lithium chloride; palladium on activated charcoal; In ethanol; acetonitrile; 1: Horner-Wadsworth-Emmons reaction / 2: Catalytic hydrogenation / 3: Condensation;
DOI:10.1016/S0968-0896(00)00177-2