(2,2,6,6-tetramethyl-3,4-heptadien-3-yl)phenylphosphinic acid

Base Information

• Chemical Name: (2,2,6,6-tetramethyl-3,4-heptadien-3-yl)phenylphosphinic acid
• CAS No.: 141091-41-0
• Molecular Formula: C₁₇H₂₅O₂P
• Molecular Weight: 292.358
• Mol file: 141091-41-0.mol

Synonyms:(2,2,6,6-tetramethyl-3,4-heptadien-3-yl)phenylphosphinic acid

Chemical Property of (2,2,6,6-tetramethyl-3,4-heptadien-3-yl)phenylphosphinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,2,6,6-tetramethyl-3,4-heptadien-3-yl)phenylphosphinic acid

There total 8 articles about (2,2,6,6-tetramethyl-3,4-heptadien-3-yl)phenylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(Z)-4-bromo-3,5-di-tert-butyl-2-phenyl-1,2-oxaphosphol-3-ene 2-oxide (141091-44-3) → (2,2,6,6-tetramethyl-3,4-heptadien-3-yl)phenylphosphinic acid (141091-41-0) + (2S,5R)-3,5-Di-tert-butyl-2-oxo-2-phenyl-2,5-dihydro-2λ5-[1,2]oxaphosphol-4-ol

Guidance literature:

(Z)-4-bromo-3,5-di-tert-butyl-2-phenyl-1,2-oxaphosphol-3-ene 2-oxide; With potassium hydride; In tetrahydrofuran; for 48h;

With trifluoroacetic acid-d₁; In tetrahydrofuran; pH=6; Further stages.;

DOI:10.1021/jo000751j

Reference yield: 22.0%

3,5-di-tert-butyl-2-phenyl-5H-[1,2]oxaphosphole 2-oxide → (2,2,6,6-tetramethyl-3,4-heptadien-3-yl)phenylphosphinic acid (141091-41-0) + (E/Z)-3,5-di-tert-butyl-2-phenyl-1,2-oxaphosphol-3-ene 2-oxide (141091-42-1,141091-43-2) + (1-tert-butyl-4,4-dimethyl-3-oxo-pentyl)-phenyl-phosphinic acid

Guidance literature:

With potassium hydride; at 20 ℃;

DOI:10.1021/jo000751j

Reference yield:

C17H24ClOP → (2,2,6,6-tetramethyl-3,4-heptadien-3-yl)phenylphosphinic acid (141091-41-0)

Guidance literature:

With sodium hydrogencarbonate; In water; at 45 ℃; for 0.75h; Yield given;

DOI:10.1021/jo00040a029

upstream raw materials:

2,2,6,6-tetramethyl-4-heptyn-3-ol

Dichlorophenylphosphine

(Z)-4-bromo-3,5-di-tert-butyl-2-phenyl-1,2-oxaphosphol-3-ene 2-oxide

(E/Z)-3,5-di-tert-butyl-2-phenyl-1,2-oxaphosphol-3-ene 2-oxide

Downstream raw materials:

(E/Z)-3,5-di-tert-butyl-2-phenyl-1,2-oxaphosphol-3-ene 2-oxide

(Z)-4-bromo-3,5-di-tert-butyl-2-phenyl-1,2-oxaphosphol-3-ene 2-oxide

(E)-4-bromo-3,5-di-tert-butyl-2-phenyl-1,2-oxaphosphol-3-ene 2-oxide

C₁₇H₂₃⁽²⁾H₂O₂P