N-((1E)-((3R,8R)-3,8-dihept-6-enyl-7-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-3,4,6,7,8,9-hexahydrodipyrido(3,4-b:3',4'-e)pyrazin-2(1H)-yl)(phenyl)methylene)-N-((1S)-1-(methoxymethyl)-2-methylpropyl)amine

Base Information

• Chemical Name: N-((1E)-((3R,8R)-3,8-dihept-6-enyl-7-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-3,4,6,7,8,9-hexahydrodipyrido(3,4-b:3',4'-e)pyrazin-2(1H)-yl)(phenyl)methylene)-N-((1S)-1-(methoxymethyl)-2-methylpropyl)amine
• CAS No.: 904930-05-8
• Molecular Formula: C₅₀H₇₂N₆O₂
• Molecular Weight: 789.161

Synonyms:N-((1E)-((3R,8R)-3,8-dihept-6-enyl-7-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-3,4,6,7,8,9-hexahydrodipyrido(3,4-b:3',4'-e)pyrazin-2(1H)-yl)(phenyl)methylene)-N-((1S)-1-(methoxymethyl)-2-methylpropyl)amine

Chemical Property of N-((1E)-((3R,8R)-3,8-dihept-6-enyl-7-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-3,4,6,7,8,9-hexahydrodipyrido(3,4-b:3',4'-e)pyrazin-2(1H)-yl)(phenyl)methylene)-N-((1S)-1-(methoxymethyl)-2-methylpropyl)amine

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Technology Process of N-((1E)-((3R,8R)-3,8-dihept-6-enyl-7-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-3,4,6,7,8,9-hexahydrodipyrido(3,4-b:3',4'-e)pyrazin-2(1H)-yl)(phenyl)methylene)-N-((1S)-1-(methoxymethyl)-2-methylpropyl)amine

There total 1 articles about N-((1E)-((3R,8R)-3,8-dihept-6-enyl-7-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-3,4,6,7,8,9-hexahydrodipyrido(3,4-b:3',4'-e)pyrazin-2(1H)-yl)(phenyl)methylene)-N-((1S)-1-(methoxymethyl)-2-methylpropyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

tert-butyl (6R)-6-hept-6-enyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxopiperidin-3-ylcarbamate → N-((1E)-((3R,8R)-3,8-dihept-6-enyl-7-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-3,4,6,7,8,9-hexahydrodipyrido(3,4-b:3',4'-e)pyrazin-2(1H)-yl)(phenyl)methylene)-N-((1S)-1-(methoxymethyl)-2-methylpropyl)amine (904930-05-8)

Guidance literature:

tert-butyl (6R)-6-hept-6-enyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxopiperidin-3-ylcarbamate; With trifluoroacetic acid; In dichloromethane; for 2h;

With sodium ethanolate; In ethanol;

DOI:10.1021/ol0609006

Reference yield:

N-((1E)-((3R,8R)-3,8-dihept-6-enyl-7-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-3,4,6,7,8,9-hexahydrodipyrido(3,4-b:3',4'-e)pyrazin-2(1H)-yl)(phenyl)methylene)-N-((1S)-1-(methoxymethyl)-2-methylpropyl)amine (904930-05-8) → C48H68N6O2 (904930-06-9)

Guidance literature:

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 100 ℃; for 36h;

DOI:10.1021/ol0609006

Reference yield:

N-((1E)-((3R,8R)-3,8-dihept-6-enyl-7-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-3,4,6,7,8,9-hexahydrodipyrido(3,4-b:3',4'-e)pyrazin-2(1H)-yl)(phenyl)methylene)-N-((1S)-1-(methoxymethyl)-2-methylpropyl)amine (904930-05-8) → C48H70N6O2

Guidance literature:

Multi-step reaction with 2 steps

1: second generation Grubbs catalyst / toluene / 36 h / 100 °C

2: hydrogen / palladium on carbon / acetonitrile / 6 h / 750.06 Torr

With hydrogen; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In toluene; acetonitrile;

DOI:10.1021/ol0609006

Downstream raw materials:

C₄₈H₆₈N₆O₂

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