Technology Process of N-(7-ethoxy-4-(3,4,5-trimethoxybenzoyl)isoquinolin-8-yl)sulfamide
There total 8 articles about N-(7-ethoxy-4-(3,4,5-trimethoxybenzoyl)isoquinolin-8-yl)sulfamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl N-(7-ethoxy-4-(3,4,5-trimethoxybenzoyl)isoquinolyl)sulfamoylcarbamate;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
With
sodium hydrogencarbonate;
In
water;
pH=7;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: toluene / 4 h / 150 °C / Inert atmosphere
2.1: ethanol; sodium tetrahydroborate / 1 h / 100 °C / Inert atmosphere
3.1: hydrogenchloride / ethanol / 0.33 h / 100 °C / Microwave irradiation
3.2: pH 7
4.1: triethylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
5.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 5 h / 150 °C / Microwave irradiation
6.1: sodium chlorite / N-hydroxyphthalimide / acetonitrile; water / 0.33 h / 120 °C / Microwave irradiation
6.2: 0.5 h / 20 °C
6.3: pH 7
7.1: tetrahydrofuran / 2 h / 0 - 20 °C
7.2: 1 h / 20 °C
7.3: 20 °C
8.1: trifluoroacetic acid / dichloromethane / 20 °C
8.2: pH 7
With
hydrogenchloride; sodium chlorite; sodium tetrahydroborate; ethanol; triethylamine; trifluoroacetic acid;
tris-(dibenzylideneacetone)dipalladium(0); N-hydroxyphthalimide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ethanol; sodium tetrahydroborate / 1 h / 100 °C / Inert atmosphere
2.1: hydrogenchloride / ethanol / 0.33 h / 100 °C / Microwave irradiation
2.2: pH 7
3.1: triethylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
4.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 5 h / 150 °C / Microwave irradiation
5.1: sodium chlorite / N-hydroxyphthalimide / acetonitrile; water / 0.33 h / 120 °C / Microwave irradiation
5.2: 0.5 h / 20 °C
5.3: pH 7
6.1: tetrahydrofuran / 2 h / 0 - 20 °C
6.2: 1 h / 20 °C
6.3: 20 °C
7.1: trifluoroacetic acid / dichloromethane / 20 °C
7.2: pH 7
With
hydrogenchloride; sodium chlorite; sodium tetrahydroborate; ethanol; triethylamine; trifluoroacetic acid;
tris-(dibenzylideneacetone)dipalladium(0); N-hydroxyphthalimide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
