[4-tert-butoxycarbonylamino-4-(4-sulfamoyl-benzylcarbamoyl)-butyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[4-tert-butoxycarbonylamino-4-(4-sulfamoyl-benzylcarbamoyl)-butyl]-carbamic acid tert-butyl ester
CAS No.:858368-18-0
Molecular Formula:C₂₂H₃₆N₄O₇S
Molecular Weight:500.616
Hs Code.:

[4-<i>tert</i>-butoxycarbonylamino-4-(4-sulfamoyl-benzylcarbamoyl)-butyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[4-tert-butoxycarbonylamino-4-(4-sulfamoyl-benzylcarbamoyl)-butyl]-carbamic acid tert-butyl ester

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Chemical Property of [4-tert-butoxycarbonylamino-4-(4-sulfamoyl-benzylcarbamoyl)-butyl]-carbamic acid tert-butyl ester

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Technology Process of [4-tert-butoxycarbonylamino-4-(4-sulfamoyl-benzylcarbamoyl)-butyl]-carbamic acid tert-butyl ester

There total 1 articles about [4-tert-butoxycarbonylamino-4-(4-sulfamoyl-benzylcarbamoyl)-butyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 138-39-6
4-homosulfanilamide

: 57133-29-6
(S)-2,5-bis((tert-butoxycarbonyl)amino)pentanoic acid

: 858368-18-0
[4-tert-butoxycarbonylamino-4-(4-sulfamoyl-benzylcarbamoyl)-butyl]-carbamic acid tert-butyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In chloroform; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1039/b501780g

Reference yield: 94.0%

: 858368-18-0
[4-tert-butoxycarbonylamino-4-(4-sulfamoyl-benzylcarbamoyl)-butyl]-carbamic acid tert-butyl ester

: (S)-2,5-Diamino-pentanoic acid 4-sulfamoyl-benzylamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 6h;
DOI:10.1039/b501780g

Reference yield:

: 858368-18-0
[4-tert-butoxycarbonylamino-4-(4-sulfamoyl-benzylcarbamoyl)-butyl]-carbamic acid tert-butyl ester

: ({3-[(S)-4-{3,5-Bis-[(bis-carboxymethyl-amino)-methyl]-benzoylamino}-1-(4-sulfamoyl-benzylcarbamoyl)-butylcarbamoyl]-5-[(bis-carboxymethyl-amino)-methyl]-benzyl}-carboxymethyl-amino)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / HCl / dioxane / 6 h / 20 °C

2: 94 percent / BOP reagent; Et₃N / CHCl₃ / 12 h / 20 °C

3: 98 percent / LiOH*H₂O / CH₂Cl₂; tetrahydrofuran; methanol / 12 h / 20 °C

With hydrogenchloride; lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform;
DOI:10.1039/b501780g