{3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

Base Information

Chemical Name:{3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid
CAS No.:1245622-75-6
Molecular Formula:C₁₃H₉ClF₃N₃O₃
Molecular Weight:347.681
Hs Code.:

Synonyms:{3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

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Chemical Property of {3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

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Technology Process of {3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

There total 7 articles about {3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1245622-74-5
methyl {3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate

: 1245622-75-6
{3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

Guidance literature:: methyl {3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate; With water; lithium hydroxide; In methanol; at 20 ℃; for 1h;

With hydrogenchloride; In methanol;

Reference yield:

: 1228650-25-6
5-(4-chlorophenyl)-4-[⁽²⁸⁾-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 1245622-75-6
{3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

2: ethyl acetate; 2-Methylpentane / Resolution of racemate

3: dmap; trifluoromethanesulfonic acid anhydride / pyridine / 12 h / 20 °C

4: water; lithium hydroxide / methanol / 1 h / 20 °C

With dmap; water; potassium carbonate; trifluoromethanesulfonic acid anhydride; potassium iodide; lithium hydroxide; In pyridine; methanol; 2-Methylpentane; ethyl acetate; acetonitrile;

Reference yield:

: 959140-57-9
methyl {3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate

: 1245622-75-6
{3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ethyl acetate; 2-Methylpentane / Resolution of racemate

2: dmap; trifluoromethanesulfonic acid anhydride / pyridine / 12 h / 20 °C

3: water; lithium hydroxide / methanol / 1 h / 20 °C

With dmap; water; trifluoromethanesulfonic acid anhydride; lithium hydroxide; In pyridine; methanol; 2-Methylpentane; ethyl acetate;