(3R,αS,3'R,α'S)-di-tert-butyl benzene-1,4-bis[3-(N-benzyl-N-α-methylbenzylamino)propanoate]

Base Information

Chemical Name:(3R,αS,3'R,α'S)-di-tert-butyl benzene-1,4-bis[3-(N-benzyl-N-α-methylbenzylamino)propanoate]
CAS No.:403705-00-0
Molecular Formula:C₅₀H₆₀N₂O₄
Molecular Weight:753.037
Hs Code.:

Synonyms:(3R,αS,3'R,α'S)-di-tert-butyl benzene-1,4-bis[3-(N-benzyl-N-α-methylbenzylamino)propanoate]

Suppliers and Price of (3R,αS,3'R,α'S)-di-tert-butyl benzene-1,4-bis[3-(N-benzyl-N-α-methylbenzylamino)propanoate]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,αS,3'R,α'S)-di-tert-butyl benzene-1,4-bis[3-(N-benzyl-N-α-methylbenzylamino)propanoate]

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,αS,3'R,α'S)-di-tert-butyl benzene-1,4-bis[3-(N-benzyl-N-α-methylbenzylamino)propanoate]

There total 12 articles about (3R,αS,3'R,α'S)-di-tert-butyl benzene-1,4-bis[3-(N-benzyl-N-α-methylbenzylamino)propanoate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 17480-69-2
(S)-N-benzyl-1-phenylethylamine

: 425431-81-8
(3R,αS,E)-tert-butyl 3-(N-benzyl-N-α-methylbenzylamino)-3-[4-(3-tert-butoxy-3-oxoprop-1-enyl)phenyl]propanoate

: 403705-00-0
(3R,αS,3'R,α'S)-di-tert-butyl benzene-1,4-bis[3-(N-benzyl-N-α-methylbenzylamino)propanoate]

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 12h;
DOI:10.1016/S0040-4020(02)00369-1

Reference yield: 80.0%

: lithium N-benzyl-N-((S)-1-phenylethyl)amide

: 173196-50-4
(E,E')-di-tert-butyl benzene-1,4-dipropenoate

: 403705-00-0
(3R,αS,3'R,α'S)-di-tert-butyl benzene-1,4-bis[3-(N-benzyl-N-α-methylbenzylamino)propanoate]

Guidance literature:: lithium N-benzyl-N-((S)-1-phenylethyl)amide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(E,E')-di-tert-butyl benzene-1,4-dipropenoate; In tetrahydrofuran; hexane; at -78 ℃; for 12h; Further stages.;
DOI:10.1039/b107440g

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 403705-00-0
(3R,αS,3'R,α'S)-di-tert-butyl benzene-1,4-bis[3-(N-benzyl-N-α-methylbenzylamino)propanoate]

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / tri-o-tolyl phosphine; Pd(OAc)2; NEt₃ / Heating

2: 81 percent / n-butyllithium / tetrahydrofuran / 12 h / -78 °C

3: 89 percent / n-butyllithium / tetrahydrofuran / 12.5 h / -78 - 20 °C

4: 82 percent / n-butyllithium / tetrahydrofuran / 12 h / -78 °C

With palladium diacetate; n-butyllithium; triethylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; 3: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/S0040-4020(02)00369-1